The role of the dorsal striatum in a mouse model for fragile X syndrome: Behavioral and dendritic spine assessment.

Fragile X syndrome (FXS), a leading monogenic cause of autism spectrum disorders (ASDs), typically occurs as the result of a mutation silencing the Fmr1 gene, preventing production of the fragile X messenger ribonucleoprotein (FMRP). FXS is characterized, in part, by hyperactivity, impaired behavioral flexibility, and the development of repetitive, or stereotyped, behaviors. While these phenotypes are influenced by striatal activity, few studies have examined FXS or FMRP in the context of striatal function.

Visibility of tobacco products and advertisement at the point of sale: a systematic audit of retailers in Amsterdam.

Objectives: Visibility of tobacco products at the point of sale (PoS), in settings where open display of tobacco is allowed, is one of the last remaining ways in which the tobacco industry can legally promote their products. The aim of this study was to map the visibility of tobacco products and advertisement both inside and outside retailers, among different types of retailers.

Setting: The study was conducted in two districts in Amsterdam, the Netherlands.