Clinical Epidemiology and Phenotypic Characteristics of Hidradenitis Suppurativa Disease in the Central Region of Saudi Arabia: Findings from a Cross-Sectional.

Background: Hidradenitis suppurativa (HS) is a complex condition that is often misdiagnosed, and regional data on its clinical features and risk factors are limited. This study aimed to explore the clinical epidemiology and phenotypic characteristics of HS in the central region of Saudi Arabia.

Materials And Methods: A cross-sectional study was conducted on HS patients at King Khalid University Hospital (KKUH) in Riyadh from December 2020 to December 2021.

The Impact of Idiopathic Intracranial Hypertension on Cardiovascular Disease Risk Among UK Women: An Obesity-Adjusted Analysis.

Introduction: Idiopathic intracranial hypertension (IIH) is known to elevate cardiovascular disease (CVD) risk, but the extent to which obesity and IIH-specific factors contribute to this risk is not well understood. WE aim to separate the effects of obesity from IIH-specific factors on the risk of stroke and CVD, building on previous findings that indicate a two-fold increase in cardiovascular events in women with IIH compared to BMI-matched controls.

Methods: An obesity-adjusted risk analysis was conducted using Indirect Standardization based on data from a cohort study by Adderley et al.

Assessing the Causes of Acceptance or Refusal of Breast Cosmetic Procedures Among Saudi Women When They Get to Age of Menopause: A Cross Sectional Study-Saudi Arabia.

Introduction: Cosmetic breast surgery encompasses a variety of procedures aimed at enhancing breast appearance and is increasingly popular globally. Despite this trend, the acceptance of such surgeries among Saudi women approaching menopause remains understudied. This research aims to explore the attitudes and perceptions toward cosmetic breast surgery in this demographic, considering cultural and religious influences in Saudi Arabia.

Potential of Sodium-Glucose Cotransporter-2 Inhibitors in the Management of Heart Failure With Preserved Ejection Fraction: A Narrative Review.

Heart failure with preserved ejection fraction presents a major clinical challenge due to its complex pathophysiology and limitations in its therapeutic options. This comprehensive review explores the comparative effectiveness of sodium-glucose cotransporter-2 inhibitors, focusing on their impact on diabetic versus non-diabetic patients, individuals with chronic kidney disease, and the elderly. A comprehensive literature search identified randomized controlled trials, meta-analyses, and clinical studies that evaluated the role of sodium-glucose cotransporter-2 inhibitors in managing heart failure with preserved ejection fraction.

The prevelance of food allergy in patients with chronic idiopathic urticaria: a systematic review and meta-analysis.

Chronic idiopathic urticaria (CIU) is difficult for patients and healthcare professionals to manage owing to its chronic and unpredictable nature. While the exact cause of CIU is unknown, it is suggested that food allergies may contribute to the development of symptoms. To determine the prevalence of food allergy in patients diagnosed with CIU.

Cardiometabolic Outcomes in Idiopathic Intracranial Hypertension: An International Matched-Cohort Study.

Introduction: Idiopathic intracranial hypertension (IIH) has been traditionally viewed as a neuro-ophthalmic disorder, yet emerging evidence suggests broader systemic implications. Our study investigates the cardiometabolic outcomes associated with IIH through a comprehensive matched-cohort analysis.

Methods: We conducted a retrospective analysis of electronic health records from 2009 to 2024.

Semaglutide as an Adjunctive Therapy to Standard Management for Idiopathic Intracranial Hypertension: A Real-World Data-Based Retrospective Analysis.

Background: Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure, predominantly affecting young women with obesity. This study evaluates the effectiveness of semaglutide as an adjunctive therapy to standard IIH management using real-world data.

Methods: We conducted a retrospective cohort analysis comparing IIH patients receiving semaglutide plus standard therapy versus standard therapy alone.

Efficacy of Tirzepatide Dual GIP/GLP-1 Receptor Agonist In Patients with Idiopathic Intracranial Hypertension. A Real-World Propensity Score-Matched Study.

Introduction: Idiopathic intracranial hypertension (IIH) is a neurological disorder characterized by elevated intracranial pressure, predominantly affecting obese women of reproductive age. While GLP-1 receptor agonists have shown promise in IIH management, the potential of dual GIP/GLP-1 receptor activation through tirzepatide remains unexplored. This study aimed to evaluate tirzepatide's efficacy as an adjunctive therapy in IIH management.

Resolution of paraneoplastic palmoplantar keratoderma after treating mixed serous neuroendocrine tumor of the pancreas: a case report and literature review.

Palmoplantar keratodermas (PPKs), also known as 'keratosis palmaris et plantaris', are a heterogeneous group of disorders characterized by abnormal thickening of the epidermal skin of the palms and soles leading to hyperkeratosis. It could be acquired or hereditary. Acquired PPK often occurs as a paraneoplastic syndrome as well as a stigma of other dermatoses.

Prevalence and Determinants of Diabetes in Saudi Arabia: A Cross-Sectional Analysis.

Background: Diabetes is a major public health challenge in Saudi Arabia, with rising prevalence and significant associated complications. The increasing burden of diabetes in the region necessitates a comprehensive understanding of its prevalence, determinants, and the effectiveness of public health strategies. This study aimed to assess the prevalence and determinants of diabetes using online assessment tools.

Exploring Regulatory Roles of Transposable Elements in EMT and MET through Data-Driven Analysis: Insights from regulaTER.

Gene expression is regulated at the transcriptional and translational levels and a plethora of epigenetic mechanisms. Regulation of gene expression by transposable elements is well documented. However, a comprehensive analysis of their regulatory roles is challenging due to the lack of dedicated approaches to define their contribution.

Cutaneous Myiasis in a Healthy Young Adult From Saudi Arabia: A Report of a Rare Case.

Myiasis is a parasitic infection of the skin tissue caused by larvae, which are commonly known as maggots, that is typically observed in the tropical and subtropical areas of Africa and the Americas. Cutaneous myiasis is the most prevalent form of myiasis and is categorized as furuncular, creeping (migratory), or wound (traumatic) myiasis based on its clinical presentation. Few cases of cutaneous myiasis have been observed in Saudi Arabia, and most of these have been observed in southern Saudi Arabia.

Characteristics and distribution of respiratory therapy practitioners in Saudi Arabia: national cross-sectional results.

Background: Respiratory therapy services commenced in Saudi Arabia (SA) in the mid-1970s. Since then, respiratory therapists have become integral members of the healthcare team. However, data about the characteristics and distribution of the respiratory therapy workforce in SA are limited.

Performance of respiratory therapy programs in the Saudi Respiratory Care Licensure Examination: Cross-sectional national results.

Recently, there has been an increase in the number of respiratory therapy programs. However, a national consensus is lacking in intended learning objectives, appropriate teaching methods, and suitable assessment tools. Consequently, variations in outcomes among these programs are expected.

Controlled Delivery of Ketoconazole an Antifungal Agent from Uncemented Titanium Using a Layer-by-Layer Technique.

This study aims to evaluate the effectiveness of a layer-by-layer (LbL) technique for delivering ketoconazole to prevent fungi prosthetic joint infection (PJI) LbL assembly is a versatile technique for functionalizing biomaterial surfaces and engineering objects such as capsules and films through electrostatic attraction. This method involves the cyclic deposition of various materials onto substrates, allowing for the controlled growth of thin films. One of the key advantages of LbL assembly is its ability to create stable, nanoscale films with organized structures and customizable compositions on a range of substrates, which only need to carry electrostatic charges.

Quality of Life and Health Awareness Among Patients With Hypertension in Urban and Rural Regions of Riyadh City, Saudi Arabia.

Background: Hypertension is a leading global health issue and a major risk factor for cardiovascular diseases. Understanding the differences in quality of life (QoL) and health awareness among hypertensive patients in urban and rural regions is critical for developing targeted interventions to improve health outcomes. This study aims to assess the health-related quality of life (HRQoL) and health awareness among hypertensive patients in Riyadh, Saudi Arabia.

Computational analysis of controlled drug release from porous polymeric carrier with the aid of Mass transfer and Artificial Intelligence modeling.

Controlled release of a desired drug from porous polymeric biomaterials was analyzed via computational method. The method is based on simulation of mass transfer and utilization of artificial intelligence (AI). This study explores the efficacy of three regression models, i.

Relationship between dominant decision-making style and creativity of nursing managers: A cross-sectional study.

Objective: This study aims to investigate the connection between dominant decision-making style and creativity among nursing managers.

Background: The dominant style of decision-making nursing managers use definitely affects the quality of decisions. Also, in another way, it can develop a skill of creative thinking that may influence the entire health care system.

Retinal Pigment Epithelial Proliferation Secondary to Retinal Ischemia: A Case Report and Literature Review.

Introduction: Antiphospholipid syndrome is one of the most common causes of acquired hypercoagulable conditions which is correlated with ocular conditions not least of which is retinal ischemia due to arterial or venous occlusive insults.

Case Presentation: We describe a case of unilateral retinal ischemia in the setting of combined central retinal artery and vein occlusion with associated proliferation of retinal pigment epithelium. The patient was worked-up for the etiology of her presentation which was found to be antiphospholipid syndrome.

Spontaneous space closure after extraction of young first permanent molar. Retrospective cohort study.

Background: Early compromised first-permanent-molar (FPM) extraction can adversely affect occlusion. However, the current literature does not provide sufficient support for definitive early extraction outcome. This cohort study aimed to evaluate the pattern of post-FPM extraction spontaneous space closure and its pre-extraction indicators.

Competency of Family Medicine Residents in Performing Skin Cancer Examination.

Early recognition of skin cancer reduces associated morbidity and improves survival. Most patients with suspicious skin lesions present to family medicine physicians. We aimed to evaluate the self-reported competency of family medicine residents in performing skin cancer examination (SCE) and assess the impact of different factors on their competency.