Experimental setup for labyrinth seals: Pressure, temperature, mass flow rate, rotation velocity, and pressure drop simultaneous measurement.

Labyrinth seals (LSs) in turbomachinery are used to minimize leaks. This study presents an experimental setup designed to test and validate LS designs. The test bench (TB) described in this paper can evaluate different LS designs obtained through various methods to find better solutions to mitigate greenhouse gas (GHG) emissions.

The Value of Bone Marrow Assessment by FDG PET/CT, Biopsy and Aspirate in the Upfront Evaluation of Mantle Cell Lymphoma: A Nationwide Cohort Study.

Background: Assessment of bone marrow infiltration (BMI) is part of the initial staging of mantle cell lymphoma (MCL), although BMI evaluated by biopsy (BMB) is not considered significant in the MIPI scales, and standardized recommendations remain lacking.

Objectives: To evaluate the accuracy and prognostic impact of BMI assessed by PET/CT and BMB in a large series of MCL patients.

Methods: We deconstructed the IPI-NCCN, MIPI, and MIPI-c indices and considered BMI as positive if indicated by a BMB, PET/CT scan, or a combination of both.

Selective Pressure Influences Inter-Biome Dispersal in the Assembly of Saline Microbial Communities.

Selection and dispersal are the primary processes influencing community assembly at both global and regional scales. Although the effectiveness of dispersal is often examined within the same biome, microscopic organisms demonstrate the capability to colonise and thrive across different biomes. In this study, we evaluated the relationship between (i) aquatic, (ii) sedimentary and (iii) aerial microbial communities, and how local selective pressures influence the potential impact of inter-biome dispersal, focusing on the salinity gradient stress over time in ephemeral saline lakes.

Complication of Gastric Balloon in an Adolescent Patient: A Case Report.

As the prevalence of childhood obesity continues to rise, there is an increase in demand for temporary and minimally invasive alternatives to bariatric surgery as solutions for addressing pediatric obesity. Intragastric balloon (IGB) placement is an increasingly popular methodology for addressing adult obesity; however, it is not approved for the pediatric population. We describe the case of a 17-year-old adolescent female who underwent IGB placement in Colombia and failed to receive proper follow-up care in the country of insertion resulting in a gastric outlet obstruction.

Blood matters: the hematological signatures of Coronavirus infection.

Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses.

Unmasking Neuroendocrine Prostate Cancer with a Machine Learning-Driven Seven-Gene Stemness Signature That Predicts Progression.

Prostate cancer (PCa) poses a significant global health challenge, particularly due to its progression into aggressive forms like neuroendocrine prostate cancer (NEPC). This study developed and validated a stemness-associated gene signature using advanced machine learning techniques, including Random Forest and Lasso regression, applied to large-scale transcriptomic datasets. The resulting seven-gene signature (, , , , , , and ) was validated across independent cohorts and patient-derived xenograft (PDX) models.

Present and future suitability of invasive and urban vectors through an environmentally driven mosquito reproduction number.

Temperature and water availability significantly influence mosquito population dynamics. We have developed a method, integrating experimental data with insights from mosquito and thermal biology, to calculate the basic reproduction number ([Formula: see text]) for urban mosquito species and . [Formula: see text] represents the number of female mosquitoes produced by one female during her lifespan, indicating suitability for growth.

Evaluation of Aedes aegypti control intervention with pyriproxyfen by lcWGS in Manacapuru, Amazonas, Brazil.

Background: Ae. aegypti mosquitoes are considered a global threat to public health due to its ability to transmit arboviruses such as yellow fever, dengue, Zika and Chikungunya to humans. The lack of effective arboviral vaccines and etiological treatments make vector control strategies fundamental in interrupting the transmission cycle of these pathogens.

Effect on Satiety-Related Biomarkers of Bar Snacks Containing Chickpea Flour and Pork Protein.

Unlabelled: This project aims to establish the acceptability and satiety of a hybrid snack containing plant protein and a small percentage of animal protein compared to a meat-based snack.

Design: Randomised, crossover, double-blind, controlled post-prandial trial involving 24 participants (18-30 years), with two interventions: (a) a hybrid snack containing plant protein derived from chickpeas and 6.6% lean high-quality pork meat; and (b) a meat-based snack containing 90% lean pork meat.

Could alternative pathways for carotenoid transformation affect colour production efficiency? A correlative study in wild common crossbills (Loxia curvirostra).

In many vertebrates, dietary yellow carotenoids are enzymatically transformed into 4C-ketocarotenoid pigments, leading to conspicuous red colourations. These colourations may evolve as signals of individual quality under sexual selection. To evolve as signals, they must transmit reliable information benefiting both the receiver and the signaler.

Fungal Enzymes for Saccharification of Gamma-Valerolactone-Pretreated White Birch Wood: Optimization of the Production of Cellulolytic Cocktail.

Lignocellulosic biomass, the most abundant natural resource on earth, can be used for cellulosic ethanol production but requires a pretreatment to improve enzyme access to the polymeric sugars while obtaining value from the other components. γ-Valerolactone (GVL) is a promising candidate for biomass pretreatment since it is renewable and bio-based. In the present work, the effect of a pretreatment based on GVL on the enzymatic saccharification of white birch was evaluated at a laboratory scale and the importance of the washing procedure for the subsequent saccharification was demonstrated.

Impact of Long-Term Pyriproxyfen Exposure on the Genetic Structure and Diversity of and in Manaus, Amazonas, Brazil.

and are responsible for transmitting major human arboviruses such as Dengue, Zika, and Chikungunya, posing a global threat to public health. The lack of etiological treatments and efficient vaccines makes vector control strategies essential for reducing vector population density and interrupting the pathogen transmission cycle. This study evaluated the impact of long-term pyriproxyfen exposure on the genetic structure and diversity of and mosquito populations.

X-Ray-Cosmic-Shear Cross-Correlations: First Detection and Constraints on Baryonic Effects.

We report the first detection, at very high significance (23σ), of the cross-correlation between cosmic shear and the diffuse x-ray background, using data from the Dark Energy Survey and the ROSAT satellite. The x-ray cross-correlation signal is sensitive to the distribution of the surrounding gas in dark matter halos. This allows us to use our measurements to place constraints on key physical parameters that determine the impact of baryonic effects in the matter power spectrum.

Translational T-box riboswitches bind tRNA by modulating conformational flexibility.

T-box riboswitches are noncoding RNA elements involved in genetic regulation of most Gram-positive bacteria. They regulate amino acid metabolism by assessing the aminoacylation status of tRNA, subsequently affecting the transcription or translation of downstream amino acid metabolism-related genes. Here we present single-molecule FRET studies of the Mycobacterium tuberculosis IleS T-box riboswitch, a paradigmatic translational T-box.

Convergent evolution of plant prickles by repeated gene co-option over deep time.

An enduring question in evolutionary biology concerns the degree to which episodes of convergent trait evolution depend on the same genetic programs, particularly over long timescales. In this work, we genetically dissected repeated origins and losses of prickles-sharp epidermal projections-that convergently evolved in numerous plant lineages. Mutations in a cytokinin hormone biosynthetic gene caused at least 16 independent losses of prickles in eggplants and wild relatives in the genus .

Recent Advances on the Catalytic Asymmetric Allylic α-Alkylation of Carbonyl Derivatives Using Free Allylic Alcohols.

During the last years, the development of more sustainable and straightforward methodologies to minimize the generation of waste organic substances has acquired high importance within synthetic organic chemistry. Therefore, it is not surprising that many efforts are devoted to ameliorating already well-known successful methodologies, that is, the case of the asymmetric allylic allylation reaction of carbonyl compounds. The use of free alcohols as alkylating agents in this transformation represents a step forward in this sense since it minimizes waste production and the substrate manipulation.

Liver Transplant Costs and Activity After United Network for Organ Sharing Allocation Policy Changes.

Importance: A new liver allocation policy was implemented by United Network for Organ Sharing (UNOS) in February 2020 with the stated intent of improving access to liver transplant (LT). There are growing concerns nationally regarding the implications this new system may have on LT costs, as well as access to a chance for LT, which have not been captured at a multicenter level.

Objective: To characterize LT volume and cost changes across the US and within specific center groups and demographics after the policy implementation.

Children's attitudes about transgender identity disclosure and concealment.

Supportive peers are crucial for transgender children's well-being. Transgender children who live in their affirmed gender face decisions surrounding concealment and disclosure of their transgender identity. We sought to understand how cisgender (N = 115) and gender-diverse children (N = 127), and siblings of gender-diverse children (N = 63) think about transition disclosure and concealment.

Memory biases for gender-typed images in a gender-diverse group of children.

Self-socialization accounts of gender development suggest that children attend more to people of their own gender, activities associated with their own gender and stereotype-consistent examples in their environment. Evidence comes from research showing children's memory biases for such stimuli. This study sought to replicate these memory biases in 367 6- to 11-year-old transgender, cisgender and nonbinary children.

Epidemiology and Risk Factors of Mycotic Aneurysm in Patients With Infective Endocarditis and the Impact of its Rupture in Outcomes. Analysis of a National Prospective Cohort.

Background: Several aspects of the occurrence and management of mycotic aneurysm (MA) in patients with infective endocarditis (IE) have not been studied.

Objectives: To determine the incidence and factors associated with MA presence and rupture and to assess the evolution of those initially unruptured MA.

Methods: Prospective multicenter cohort including all patients with definite IE between January 2008 and December 2020.

Production of Methyl Lactate with Sn-USY and Sn-β: Insights into Real Hemicellulose Valorization.

Potassium exchanged Sn-β and Sn-USY zeolites have been tested for the transformation of various aldoses (hexoses and pentoses), exhibiting outstanding catalytic activity and selectivity toward methyl lactate. Insights into the transformation pathways using reaction intermediates-dihydroxyacetone and glycolaldehyde-as substrates revealed a very high catalytic proficiency of both zeolites in aldol and retro-aldol reactions, showcasing their ability to convert small sugars into large sugars, and vice versa. This feature makes the studied Sn-zeolites outstanding catalysts for the transformation of a wide variety of sugars into a limited range of commercially valuable alkyl lactates and derivatives.