lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR‑495‑3p/MYCBP axis.

Colorectal cancer (CRC) is a tumor type characterized by high patient morbidity and mortality. It has been reported that long non‑coding (lncRNA) LUNAR1 (LUNAR1) participates in the regulation of tumor progression, such as diffuse large B‑cell lymphoma. However, its role and underlying mechanisms in CRC progression have not been elucidated.

Photocatalytic Degradation of Bisphenol-A using N, Co Codoped TiO Catalyst under Solar Light.

Advanced oxidation processes (AOPs) including heterogeneous photocatalysis has proven as one of the best technique for waste-water treatment. Photocatalytic process using semiconductor like TiO based heterogeneous photocatalysis is a promising method for the treatment of toxic pollutants. In the present study, visible-light photoactive cobalt and nitrogen co-doped TiO nanoparticles were synthesized via wet impregnation method.

Lack of functionally active sweet taste receptors in the jejunum in vivo in the rat.

Background: When studied in enterocyte-like cell lines (Caco-2 and RIE cells), agonists and antagonists of the sweet taste receptor (STR) augment and decrease glucose uptake, respectively. We hypothesize that exposure to STR agonists and antagonists in vivo will augment glucose absorption in the rat.

Materials And Methods: About 30-cm segments of jejunum in anesthetized rats were perfused with iso-osmolar solutions containing 10, 35, and 100 mM glucose solutions (n = 6 rats, each group) with and without the STR agonist 2 mM acesulfame potassium and the STR inhibitor 10 μM U-73122 (inhibitor of the phospholipase C pathway).

Tube pharyngostomy--a useful alternative for long-term enteric decompression or enteral feeding.

The tube pharyngostomy has been all but forgotten in recent years, and rightfully so when a PEG or PEJ is possible. Nevertheless, the tube pharyngostomy should remain in the armamentarium of the GI surgeon for selected patients in whom longer term enteral access is not available by PEG or PEJ for various technical reasons, for those who absolutely refuse a nasoenteric tube, or as terminal palliation in patients with nonoperable but obstructing intra-abdominal neoplasms. Not only is it easy to place (albeit requiring a brief general anesthetic), but these tubes are much more comfortable than the “misery” to the patient of a nasoenteric tube by avoiding the annoying nasal and nasopharyngeal irritation,sinusitis, trouble with speech and coughing, and general discomfort of a longer term, indwelling nasoenteric tube.