Publications by authors named "Alok C Pradhan"
Nat Commun
September 2024
Article Synopsis
- Ring-shaped DNA sliding clamps are crucial for DNA replication and maintenance, requiring clamp loader complexes (CLCs) to open and position them on DNA.
- The study presents six detailed structures of E. coli CLC with open and closed clamps before and after DNA binding, highlighting key steps in the loading process.
- Findings reveal that the ATP-bound CLC first 'grabs' the clamp, then opens it enough for DNA to enter, ultimately allowing the clamp to close around the DNA.
