Pharmacokinetics and Bioavailability of the GnRH Analogs in the Form of Solution and Zn-Suspension After Single Subcutaneous Injection in Female Rats.

Background And Objectives: Although many synthetic gonadoliberin analogs have been developed, only a few of them, including buserelin, were introduced into clinical practice. Dalarelin, which differs from buserelin by just one aminoacid in the position 6 (D-Ala), is not widely used so far. Gonadotropin-releasing hormone (GnRH) analogs are used to treat many different illnesses and are available in different forms like solution for injection, nasal spray, microspheres, etc.

From mild cognitive impairment to Alzheimer's disease - influence of homocysteine, vitamin B12 and folate on cognition over time: results from one-year follow-up.

Background And Purpose: People with mild cognitive impairment (MCI) have higher risk of developing dementia than the general population. Currently known risk factors for dementia include older age, low education level, gait disorders, hippocampal atrophy, and apolipoprotein E allele. Vascular risk factors may modify the neurodegenerative process.

Selenium levels in blood of upper Silesian population: evidence of suboptimal selenium status in a significant percentage of the population.

The selenium status and the relationship of whole-blood selenium and plasma homocysteine are reported for healthy human subjects living in Upper Silesia. A total of 1063 individuals (627 male and 436 female) examined for whole-blood selenium were subdivided into six groups according to age; the youngest included adolescents (n=143) aged 10-15 yr, and the oldest were centenarians (n=132). The mean Se content was relatively low (62.

Antioxidant status in newborns and infants suffering from congenital heart defects.

There is a common view that free radicals may play an important role in tissue damage resulting from circulatory insufficiency, cardiosurgery etc. There are very few data concerning the involvement of free radical reactions in the newborns and infants suffering from congenital heart defects (CHD). Antioxidant status was evaluated in 41 newborns and infants under 1 year of age, among them 23 suffering from CHD (14 with left-to-right shunt and 9 with cyanotic heart defect) and 18 healthy controls.

Effects of a low carbohydrate diet and graded exercise during the follicular and luteal phases on the blood antioxidant status in healthy women.

The aim of this study was to examine the effect of a low-carbohydrate (L-CHO) diet and graded cycling exercise on the enzymatic and non-enzymatic blood antioxidant defence system in young eumenorrhoeic women. Seven healthy physical education students exercised incrementally until they were fatigued under four different phase-diet conditions of the menstrual cycle, i.e.