Reflectivity of the outer retina on spectral-domain optical coherence tomography as a predictor of photoreceptor cone density.

Purpose: To investigate the relationship between outer retinal reflectivity on spectral-domain optical coherence tomography and cone density in the corresponding area.

Design: Prospective cross-sectional observational study.

Methods: In this institutional-based study, 20 eyes of 10 patients presenting maculopathies with various degrees of impairment of the photoreceptor layer (central serous chorioretinopathy, chronic central serous chorioretinopathy, maculopathy associated with hydroxychloroquine, and healthy eyes) were studied.