Elevated Troponin T (TnT) in Non-acute Coronary Syndrome (ACS) Due to Dermatomyositis.

Troponin is a highly specific biomarker for myocardial injury. It plays a critical role in the diagnosis of acute coronary syndrome (ACS). However, elevated troponin levels are not exclusively due to cardiac ischemia and may be observed in many non-cardiac conditions, including inflammatory myopathies.

Perindopril Ameliorates Sodium Valproate-Induced Rat Model of Autism: Involvement of Sirtuin-1, JAK2/STAT3 Axis, PI3K/Akt/GSK-3β Pathway, and PPAR-Gamma Signaling.

Autism is a developmental disability characterized by impairment of motor functions and social communication together with the development of repetitive or stereotyped behaviors. Neither the exact etiology or the curative treatment of autism are yet completely explored. The goals of this study were to evaluate the possible effects of perindopril on a rat model of autism and to elucidate the possible molecular mechanisms that may contribute to these effects.

A Study of the Synergistic Effects of Essential Oils from and with Commercial Antibiotics against Highly Prioritized Multidrug-Resistant Bacteria for the World Health Organization.

The irrational use of antibiotics has favored the emergence of resistant bacteria, posing a serious threat to global health. To counteract antibiotic resistance, this research seeks to identify novel antimicrobials derived from essential oils that operate through several mechanisms. It aims to evaluate the quality and composition of essential oils from and ; test their antimicrobial activity against various strains; explore their synergies with commercial antibiotics; predict the efficacy, toxicity, and stability of compounds; and understand their molecular interactions through docking and dynamic simulations.

Prevalence of Enuresis in Children, Adolescents, and Young Adults Diagnosed With Attention Deficit Hyperactivity Disorder.

Background Enuresis, or bedwetting, is a common condition affecting millions of children worldwide. This can be a source of distress for both children and their families. Children, adolescents, and young adults with attention deficit hyperactivity disorder (ADHD) are at risk of developing enuresis.

Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA.

Background: Autophagy is a well-preserved mechanism essential in minimizing endoplasmic reticulum stress (ER)-related cell death. Defects in β-cell autophagy have been linked to type 1 diabetes, particularly deficits in the secretion of insulin, boosting ER stress sensitivity and possibly promoting pancreatic β-cell death. Quercetin (QU) is a potent antioxidant and anti-diabetic flavonoid with low bioavailability, and the precise mechanism of its anti-diabetic activity is still unknown.

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance therapy among Saudi children with autism.

Background: Antipsychotics, including risperidone (RIS), are frequently indicated for various autism spectrum disorder (ASD) manifestations; however, "actionable" PGx testing in psychiatry regarding antipsychotic dosing and selection has limited applications in routine clinical practice because of the lack of standard guidelines, mostly due to the inconsistency and scarcity of genetic variant data. The current study is aimed at examining the association of RIS effectiveness, according to ABC-CV and CGI indexes, with relevant pharmacokinetics (PK) and pharmacodynamics (PD) genes.

Methods: Eighty-nine ASD children who received a consistent RIS-based regimen for at least 8 weeks were included.

Feasibility Study of the Boston Naming Test for the Arab Population.

Introduction The Boston Naming Test (BNT) is a widely used US neuropsychological evaluation of confrontation naming for the examination of adults and children with learning disabilities and diagnosis of communication disorders, aphasia, dementia, and acquired brain injury or dysfunction. The purpose of the present study is to evaluate the practicality of the original English version of the 60-item BNT (BNT-60) on an Arab population and the need for a new adaptive Arabic version sensitive to cultural biases and to offer normative data that can serve as a reference for researchers and clinicians in the Gulf region, especially the Kingdom of Saudi Arabia (KSA). Data relating to the familiarity degree of the BNT-60 were also collected.

Appropriateness of anticoagulation level in older adult patients on Warfarin: A multicenter retrospective study.

Warfarin is favored over newer direct oral anticoagulants (DOACs) for many older adults. However, its use necessitates rigorous monitoring due to the fine line between toxic and therapeutic doses. Few studies have evaluated the anticoagulation quality of warfarin among elderly patients in Saudi Arabia.

Fatal Hemorrhage Due to Aorto-Enteric Fistula: A Case Report.

The abdominal aortic aneurysm (AAA) is a vascular condition that commonly affects individuals over the age of 65, leading to complications such as rupture, thrombosis, and embolization that can result in significant morbidity and mortality. Aorto-enteric fistula (AEF), a rare but life-threatening complication of abdominal aortic aneurysms, occurs when there is communication between the aneurysm and adjacent bowel loops. A 63-year-old man presented to the emergency department (ED) with severe abdominal pain, nausea, vomiting, and dark, tarry stools.

Repurposing an Antiepileptic Drug for the Treatment of Glioblastoma.

Purpose: Glioblastoma multiforme (GBM) is a grade IV, highly proliferative, and malignant form of brain tumor with a 5-year survival rate at ~ 5%. Current treatment strategies for GBM include surgery, radiation, and chemotherapy. Major challenges in GBM management include difficulties in surgical resection due to brain's vital functions and GBM metastasis, development of resistance to temozolomide (TMZ), and protection of tumor by blood brain barrier (BBB).

Ureaplasma-Driven Neonatal Neuroinflammation: Novel Insights from an Ovine Model.

Ureaplasma species (spp.) are considered commensals of the adult genitourinary tract, but have been associated with chorioamnionitis, preterm birth, and invasive infections in neonates, including meningitis. Data on mechanisms involved in Ureaplasma-driven neuroinflammation are scarce.

Prevalence of sleep disturbance and anxiety due to the COVID-19 pandemic in Saudi Arabia.

Introduction: In the COVID-19 pandemic, physical and psychological health are of immense concern for the governing bodies and health policymakers in the period of lockdown and self-isolation. An in-depth analysis is required to recognize the changes in mental health among the public of different geographical areas.

Objective: The study aimed to investigate the sleep quality and anxiety among the population in Saudi Arabia during the lockdown period from March to June 2020.

Quantifying Clinical Pharmacist Activities in a Tertiary Care Hospital Using Key Performance Indicators.

Key performance indicators (KPIs) are a set of measures used to help an organization in assessing and achieving goals critical to success. The aim of this study was to quantify the clinical pharmacists' contribution to patient care in a tertiary care hospital using predefined clinical pharmacy KPIs. This study was a prospective, observational study conducted by the Pharmaceutical Care Division of a tertiary care hospital.

Reduction of Breakdown Pressure by Filter Cake Removal Using Thermochemical Fluids and Solvents: Experimental and Numerical Studies.

The process of well cleanup involves the removal of an impermeable layer of filter cake from the face of the formation. The inefficient removal of the filter cake imposes difficulty on fracturing operations. Filter cake's impermeable features increase the required pressure to fracture the formation.

Al-hijamah (the triple S treatment of prophetic medicine) exerts cardioprotective, tissue-protective and immune potentiating effects in thalassemic children: a pilot clinical trial.

Thalassemia is a major health problem in affected children due to iron overload, increased oxidative stress, atherogenic lipid profile and tissue-damage. This study aims at investigating the cardioprotective and tissue-protective benefits of Al-hijamah and their impact on cell-mediated immunity for treating thalassemic children. This study aimed also at investigating the tissue-clearance principle of Taibah mechanism: whenever pathological substances are to be cleared from the human body, Al-hijamah is indicated.

Tailoring of bismuth vanadate impregnated on molybdenum/graphene oxide sheets for sensitive detection of environmental pollutants 2, 4, 6 trichlorophenol.

In the present work, we reported a one pot simple colloidal-gel synthesis of molybdenum bismuth vanadate (MoBiVO). The charge transfer property of MoBiVO was improved by developing a composite with graphene oxide (GO) through sonochemical technique. The optical and morphological analysis revealed that successful formation of GO-MoBiVO composite without any other filth.

Referral Time of Advance Cancer Patients to Palliative Care Services and Its Predictors in Specialized Cancer Center.

Background and aim Globally, there is a discrepancy in whether terminal cancer patients are early referred to palliative care service (PCS) or not. A late referral can lead to a delay in treating and palliating those patients in need. The aim of this study is to investigate the referral time patterns of advanced cancer patients to PCS in Princess Noorah Oncology Center (PNOC) at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.

The first report of Methicillin-resistant (MRSA) in cystic fibrosis (CF) patients in Saudi Arabia.

Introduction: Methicillin-resistant infections have been increasingly reported in patients with cystic fibrosis (CF) who have progressive deterioration in their pulmonary function.

Objectives: To determine the prevalence of MRSA infections in CF in a tertiary care center in Saudi Arabia.

Methodology: This is a retrospective chart review conducted as part of the CF registry data from 1 January 2002 to 1 June 2016.

Complex barite filter cake removal using in-situ generated acids by thermochemicals.

In sandstone formations, the quartz particles integrate with drilling fluid solids and become part of the filter cake structure. As a result, the dissolution rate of the filter cake diminishes and reduces the removal efficiency. This paper presents a novel solution to overcome the challenges that restricts the filter cake removal process such as the presence of the quartz layer and the polymer coat.

Improving access to care for children with cancer through implementation of an electronic referral system (IMPACT): A single-center experience from Saudi Arabia.

Background: Delayed access to cancer care has been associated with childhood cancer death. Improving timely access to cancer care is the first important step in the cancer treatment journey. We introduced an electronic referral system (e-RS) to improve timely access to cancer care.

A Novel Approach to Improve Acid Diversion in Carbonate Rocks Using Thermochemical Fluids: Experimental and Numerical Study.

The distribution of acid over all layers of interest is a critical measure of matrix acidizing efficiency. Chemical and mechanical techniques have been widely adapted for enhancing acid diversion. However, it was demonstrated that these often impact the formation with damage after the acid job is completed.

The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia.

Introduction: Studies have shown that pulmonary exacerbations in cystic fibrosis (CF) patients are associated with respiratory viruses. The most common agent causing viral infections in patients with CF before the age of 3 years is respiratory syncytial virus.

Objectives: To obtain the prevalence of the different types of viral infection in CF patients and to identify its relation with the type of bacterial infection, (CFTR) mutations and pulmonary function test (PFT).

New Chemical Treatment for Permanent Removal of Condensate Banking from Different Gas Reservoirs.

Condensate banking represents a challenging problem in producing the hydrocarbon from tight gas reservoirs. The accumulation of liquid condensates around the production well can significantly impair the gas flow rate. Gas injection and hydraulic fracturing are the common techniques used to avoid the condensate development by maintaining the reservoir pressure above the dew point curve.

Molecular identification and diversity analysis of dental bacteria in diabetic and non-diabetic females from Saudi Arabia.

Periodontal disease is a chronic infectious disease, which is characterized by the damaged dental hard tissue by lactic acid generated by microorganisms after the fermentation of carbohydrates rich diet. The risk of periodontal disease is known to be higher in diabetic patients. We compared the diversity of five commonly occurring dental bacteria including , , , , and in 14 type-2 diabetic patients and equal numbers of healthy controls.

Comparative Analysis of Static and Dynamic Mechanical Behavior for Dry and Saturated Cement Mortar.

Deformational and breakage behaviors of concrete and cement mortar greatly influence various engineering structures, such as dams, river bridges, ports, tunnels, and offshore rig platforms. The mechanical and petrophysical properties are very sensitive to water content and are controlled by the liquid part in pore spaces to a large extent. The objective of this paper is to investigate the water saturation effect on the strength characteristics and deformability of cement mortar under two loading conditions, static and dynamic compression.