Publications by authors named "Almutasem Saleh"
Article Synopsis
- The Super killer (SKI) complex, known for degrading excess mRNA in the cytoplasm, has been found to have a role in the nucleus, particularly during the G2 phase of the cell cycle.
- Components SKIV2L and TTC37 are localized on chromatin and telomeres, suggesting a new function beyond their traditional role in mRNA decay.
- SKIV2L helps prevent telomere replication stress and stabilizes telomere DNA-RNA hybrids, indicating a critical role in maintaining telomere stability during cell division.
The controlled assembly of replication forks is critical for genome stability. The Dbf4-dependent Cdc7 kinase (DDK) initiates replisome assembly by phosphorylating the MCM2-7 replicative helicase at the N-terminal tails of Mcm2, Mcm4 and Mcm6. At present, it remains poorly understood how DDK docks onto the helicase and how the kinase targets distal Mcm subunits for phosphorylation.
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- MiDAC is a special group of proteins that helps control how genes are expressed in cells, especially during cell division.
- Scientists found out that MiDAC is really important for making sure chromosomes line up correctly when cells split, which is super important in cancer cells.
- Mice that don't have certain MiDAC proteins have serious problems and do not survive because their hearts and blood cell systems don’t develop correctly, showing that MiDAC has a unique and important role in the body.
The transcriptional corepressor complex CoREST is one of seven histone deacetylase complexes that regulate the genome through controlling chromatin acetylation. The CoREST complex is unique in containing both histone demethylase and deacetylase enzymes, LSD1 and HDAC1, held together by the RCOR1 scaffold protein. To date, it has been assumed that the enzymes function independently within the complex.
View Article and Find Full Text PDFThe NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities. The complex regulates the higher-order structure of chromatin, and has important roles in the regulation of gene expression, DNA damage repair and cell differentiation. HDACs 1 and 2 are recruited by the MTA1 corepressor to form the catalytic core of the complex.
View Article and Find Full Text PDFRecent proteomic studies have identified a novel histone deacetylase complex that is upregulated during mitosis and is associated with cyclin A. This complex is conserved from nematodes to man and contains histone deacetylases 1 and 2, the MIDEAS corepressor protein and a protein called DNTTIP1 whose function was hitherto poorly understood. Here, we report the structures of two domains from DNTTIP1.
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