Publications by authors named "Almudena Rocha"
Article Synopsis
- Tumor-associated macrophages (TAMs) play a significant role in the tumor microenvironment of oral squamous cell carcinomas (OSCCs) and primarily originate from circulating monocytes that differentiate locally.
- Research showed that cell culture media from OSCC cell lines, H413 and TR146, encourages monocytes to become M2 macrophages, which are characterized by high CD163 and CD206 expression and low levels of activation markers.
- Additionally, the study identified specific soluble proteins in the media that promote this differentiation and linked it to an immunosuppressive profile that hinders T cell activation, shedding light on how OSCCs support tumor growth by altering immune cell behavior.
Colorectal cancer (CRC) and ovarian cancer (OvC) patients frequently develop peritoneal metastasis, a condition associated with a very poor prognosis. In these cancers, tumor-derived extracellular vesicles (EVs) cause immunosuppression, facilitate the direct attachment and invasion of cancer cells through the mesothelium, induce the conversion of peritoneal mesothelial cells (PMCs) into cancer-associated fibroblasts (CAFs) and transfer a more aggressive phenotype amongst cancer cells. Although the promoting role of EVs in CRC and OvC peritoneal metastasis is well established, the specific molecules that mediate the interactions between tumor-derived EVs and immune and non-immune target cells remain elusive.
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