Publications by authors named "Almudena Otalora-Alcaraz"
Multiple sclerosis (MS) is a neurological autoimmune condition associated with many symptoms including spasticity, pain, limb numbness and weakness. It is characterised by inflammatory demyelination and axonal degeneration of the brain and spinal cord. A range of disease-modifying therapies (DMTs) are available to suppress inflammatory disease activity in MS, however, there is a pressing need for new therapeutic avenues as DMTs have a limited ability to suppress confirmed disability progression.
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- * A study analyzed bronchoalveolar lavage (BAL) samples from various lung disease patients and found that high neutrophil counts correlate with a higher incidence of IPF, while higher lymphocyte counts are protective against it.
- * The findings suggest that measuring lymphocytes and neutrophils in BAL fluid could be crucial for determining the best treatment strategies for patients with ILD, impacting overall survival rates.
Toll-like receptors (TLRs) have become a focus in biomedicine and biomedical research given the roles of this unique family of innate immune proteins in immune activation, infection, and autoimmunity. It is evident that TLR dysregulation, and subsequent alterations in TLR-mediated inflammatory signalling, can contribute to disease pathogenesis, and TLR targeted therapies are in development. This review highlights evidence that cannabinoids are key regulators of TLR signalling.
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