Publications by authors named "Almudena Devesa-Peiro"
Article Synopsis
- Women's fertility declines significantly between the ages of 35-40 due to decreased ovarian activity and challenges in achieving pregnancy, both naturally and via assisted reproductive technologies.
- A systematic review of 142 studies from PubMed was conducted to explore the effects of age on the uterus and endometrium, focusing specifically on reproductive outcomes related to embryo transfers from younger egg donors.
- Results showed that advanced maternal age leads to a thinner endometrium and negatively impacts key fertility metrics, such as implantation and live birth rates, largely due to changes in uterine structure and hormone production.
Research Question: How does the intracrine action of progestagens, oestrogens, androgens and corticosteroids affect endometrial tissue progression and function?
Design: In this prospective observational study, 76 patients (<50 years old, no uterine pathologies and at least one failed IVF cycle) undergoing endometrial biopsy collection for endometrial evaluation between 2018 and 2021 were included. The concentrations of 11 steroid metabolites (cortisone, cortisol, progesterone, oestrone, 2-methoxyestrone, oestradiol, oestriol, testosterone, androstenedione, 17α-hydroxyprogesterone and 17-hydroxypregnenolone) were measured by ultra-performance liquid chromatography-tandem mass spectrometry in the endometrial tissue samples collected during the mid-secretory phase. Endometrial dating and reproductive outcomes (relative to the next good-quality fresh or frozen embryo transfer after the biopsy) were analysed in relation to endometrial steroid concentrations using Barnard's test; correlations between metabolite concentrations were measured by Pearson's correlation co-efficient.
Predicting risk of endometrial failure: a biomarker signature that identifies a novel disruption independent of endometrial timing in patients undergoing hormonal replacement cycles.
Fertil Steril
August 2024
Objective: To propose a new gene expression signature that identifies endometrial disruptions independent of endometrial luteal phase timing and predicts if patients are at risk of endometrial failure.
Design: Multicentric, prospective study.
Setting: Reproductive medicine research department in a public hospital affiliated with private fertility clinics and a reproductive genetics laboratory.
Backgorund: While various endometrial biomarkers have been characterized at the transcriptomic and functional level, there is generally a poor overlap among studies, making it unclear to what extent their upstream regulators (e.g., ovarian hormones, transcription factors (TFs) and microRNAs (miRNAs)) realistically contribute to menstrual cycle progression and function.
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- Researchers are looking for ways to find important markers in the uterus that could help with reproductive health issues like endometriosis and pregnancy problems.
- They found that many studies didn’t pay attention to which part of the menstrual cycle the samples were taken from, making it hard to discover important genes.
- By fixing this problem, they identified a lot more genes related to specific reproductive issues, helping create better guidelines for future research.
Objective: To determine the susceptibility of the endometrium to infection by-and thereby potential damage from-SARS-CoV-2.
Design: Analysis of SARS-Cov-2 infection-related gene expression from endometrial transcriptomic data sets.
Setting: Infertility research department affiliated with a public hospital.
Objective: To determine the molecular functions of genes exhibiting altered expression in the endometrium of women with uterine disorders affecting fertility.
Design: Retrospective analysis integrating case and control data from multiple cohorts with endometrium gene expression in women with uterine disorders.
Setting: Infertility research department affiliated with a university hospital.