Publications by authors named "Almardini Shaza"
Article Synopsis
- - The study investigates how type 2 diabetes mellitus (T2DM) affects the prevalence of interstitial lung disease (ILD) in patients with systemic lupus erythematosus (SLE), aiming to clarify their relationship.
- - Using data from the 2019-2020 National Inpatient Sample, researchers found that patients with SLE and T2DM had a lower prevalence of ILD compared to those without T2DM, particularly noting a reduced occurrence of pulmonary fibrosis.
- - The findings suggest that T2DM may offer some protective effects against ILD in SLE patients, and the study calls for more research into the mechanisms behind this association for improved management strategies.
Background: The impact of type 2 diabetes mellitus (T2DM) on acute respiratory distress syndrome (ARDS) is debatable. T2DM was suspected to reduce the risk and complications of ARDS. However, during coronavirus disease 2019 (COVID-19), T2DM predisposed patients to ARDS, especially those who were on insulin at home.
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- X-linked hypophosphatemia (XLH) results from mutations in the PHEX gene, leading to bone issues like rickets and enthesopathy in adults, which causes pain and movement difficulties.
- In mice models of XLH, increased bone morphogenetic protein (BMP) and Indian hedgehog (IHH) signaling were found to play a significant role in the development of enthesopathy; blocking BMP signaling with palovarotene showed a reduction in these signals.
- The study also highlights that while growth/differentiation factor 5 (GDF5) isn't crucial for BMP/IHH signaling in normal entheses, its inappropriate activity in XLH contributes to enthesopathy, suggesting that targeting G
Objective: Systematically review evidence on using GLP-1RAs for reducing BEB in BED and BN.
Methods: Comprehensive literature search (PubMed and Google Scholar) conducted for studies evaluating GLP-1Ras for BEB. Extracted data on study characteristics, efficacy, and safety.
Rheumatoid arthritis (RA), a prevalent chronic disease, poses significant treatment challenges, including side effects and high costs of conventional therapies. This heightens interest in natural, over-the-counter (OTC) anti-inflammatory supplements as potential adjunctive treatments. Given their roles in mitigating inflammation and oxidative stress, key factors in RA pathogenesis, these supplements could offer valuable therapeutic adjunctive.
View Article and Find Full Text PDFX-linked hypophosphatemia (XLH) is characterized by high serum fibroblast growth factor 23 (FGF23) levels, resulting in impaired 1,25-dihydroxyvitamin D3 (1,25D) production. Adults with XLH develop a painful mineralization of the tendon-bone attachment site (enthesis), called enthesopathy. Treatment of mice with XLH (Hyp) with 1,25D or an anti-FGF23 Ab, both of which increase 1,25D signaling, prevents enthesopathy.
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