Publications by authors named "Alma Gurrola-Silva"
NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia.
Front Oncol
November 2022
NK cells have unique attributes to react towards cells undergoing malignant transformation or viral infection. This reactivity is regulated by activating or inhibitory germline encoded receptors. An impaired NK cell function may result from an aberrant expression of such receptors, a condition often seen in patients with hematological cancers.
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- A study focused on the prevalence of genetic rearrangements associated with a good prognosis in children with acute lymphoblastic leukemia (ALL) in Mexico found lower rates compared to Caucasian populations.
- Researchers developed a new TaqMan RT-qPCR method to assess four specific genetic rearrangements in Hispanic children with ALL from Mexico City.
- The findings revealed a low prevalence of these rearrangements (7.7%, 3.3%, and 2.8%), aligning with previous studies on Mexican and Hispanic children, highlighting the need to further understand genetic factors in ALL among diverse populations.
Copy Number Alterations are Associated with the Risk of Very Early Relapse in Pediatric B-lineage Acute Lymphoblastic Leukemia: A Nested Case-control MIGICCL Study.
Arch Med Res
May 2021
Background: Refining risk stratification to avoid very early relapses (VER) in Mexican patients with B-lineage acute lymphoblastic leukemia (B-ALL) could lead to better survival rates in our population.
Aim Of The Study: The purpose of this study was to investigate the association between the United Kingdom ALL (UKALL)-CNA classifier and VER risk in Mexican patients with childhood B-ALL.
Methods: A nested case-control study of 25 cases with VER and 38 frequency-matched controls without relapse was conducted within the MIGICCL study cohort.