Reproducibility of quantitative optical coherence tomography subanalysis in neovascular age-related macular degeneration.

Purpose: To determine the intergrader reproducibility for computer-assisted grading of optical coherence tomography (OCT) images in eyes with neovascular age-related macular degeneration (AMD), by using a standardized grading procedure.

Methods: Sixty OCT image sets (of six radial lines each) were independently analyzed by two graders using validated custom software (OCTOR) to draw boundaries manually on OCT B-scans. Spaces delineated by these boundaries included retina, subretinal fluid, subretinal tissue, and pigment epithelial detachments (PEDs).

Quantitative comparison of optical coherence tomography after pegaptanib or bevacizumab in neovascular age-related macular degeneration.

Purpose: To demonstrate the benefit of enhanced quantitative analysis of optical coherence tomography (OCT) images using computer-assisted grading to compare the short-term morphologic effects of pegaptanib and bevacizumab treatment for neovascular age-related macular degeneration (AMD).

Design: Retrospective consecutive case series.

Participants: Fifty-three cases with neovascular AMD undergoing pegaptanib or bevacizumab therapy.

Error correction and quantitative subanalysis of optical coherence tomography data using computer-assisted grading.

Purpose: To demonstrate feature subanalysis and error correction of optical coherence tomography (OCT) data by using computer-assisted grading.

Methods: The raw exported StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA) scan data from 20 eyes of 20 patients were analyzed using custom software (termed OCTOR) designed to allow the user to define manually the retinal borders on each radial line scan.