Synopsis of recent research by authors named "Allyson Roe"
- Allyson Roe's research primarily focuses on the interactions between amyloid-beta and tau proteins in the context of Alzheimer's disease, exploring how these proteins contribute to neurodegeneration and cognitive decline through various mechanisms.
- Her studies emphasize the complex role of apolipoprotein E (APOE) in neuroprotection and neurotoxicity, revealing how different APOE isoforms affect amyloid-beta deposition and synaptic integrity, particularly in aging and Alzheimer's models.
- Roe's work also investigates the role of microglia in tau pathology and the potential therapeutic strategies targeting tau reduction as a means to prevent neuronal death and pathological progression in tauopathies.