Publications by authors named "Allyson Reid"
Article Synopsis
- Patients with AQP4-IgG+ neuromyelitis optica spectrum disorders (NMOSDs) often experience optic neuritis, leading to retinal nerve damage, but the link between this damage and primary astrocytopathy is unclear.
- This study compared retinal layer changes among 197 AQP4-IgG+ patients, 32 MOG-IgG+ patients, and 75 healthy controls using optical coherence tomography (OCT) and found no significant thinning in the outer retinal layers of AQP4-IgG+ patients.
- The research indicates that outer retinal damage may not be a consistent outcome of retinal astrocytic injury in AQP4-IgG+ NMOSD, suggesting the need
Retinal Optical Coherence Tomography in Neuromyelitis Optica.
Neurol Neuroimmunol Neuroinflamm
November 2021
Background And Objectives: To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) in a large international cohort after previous studies have been limited by small and heterogeneous cohorts.
Methods: The cross-sectional Collaborative Retrospective Study on retinal optical coherence tomography (OCT) in neuromyelitis optica collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD and 72 healthy controls (HCs).
Purpose: Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD.
View Article and Find Full Text PDFCollaborative International Research in Clinical and Longitudinal Experience Study in NMOSD.
Neurol Neuroimmunol Neuroinflamm
September 2019
Objective: To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment.
Methods: To illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks.
Results: As of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.
Mortality in neuromyelitis optica is strongly associated with African ancestry.
Neurol Neuroimmunol Neuroinflamm
July 2018