Publications by authors named "Allyson N Pfeil"
Arthroscopic Debridement After Total Knee Arthroplasty Is More Effective for Synovitis Than for Ankylosis.
Arthrosc Sports Med Rehabil
October 2024
Purpose: To investigate the effects of arthroscopy surgery on ankylosis and synovitis after total knee arthroplasty (TKA), with patient satisfaction as the main outcome measure.
Methods: A single surgeon's database was queried for all knee arthroscopy procedures done from 2002 to 2024 using the , and , codes for ankylosis or synovitis and Current Procedural Terminology codes 29884 and 29876. Patients were excluded if they did not have a previous TKA, had a TKA but arthroscopy was done for multiple or other indications, were <2 months from TKA, lacked medical records, or were worker's compensation cases.
Background: Conversion total hip arthroplasty (THA) includes a variety of operations and prior implants. The implant present before conversion may influence the outcome and complexity of the procedure. The group hypothesized that conversion arthroplasty for patients with intramedullary nails (IMNs) is more complex from a surgical and resource utilization perspective than for those with screw fixation.
View Article and Find Full Text PDFBackground: The 22-modifier requests additional compensation for increased case complexity. Unfortunately, there is little to guide physicians on the application, which may increase successful reimbursement. We sought to evaluate various factors affecting reimbursement of the 22-modifier in primary total joint arthroplasty (TJA) and report which factors contributed to successful utilization.
View Article and Find Full Text PDFArticle Synopsis
- Effective treatment options are needed for non-small cell lung cancer patients with EGFR mutations who develop resistance to EGFR-targeting drugs due to a process called epithelial-to-mesenchymal transition (EMT).
- The study identifies CD70 as a key protein that is significantly increased in cells that show resistance and is linked to cellular survival and invasiveness, especially in drug-tolerant persister cells (DTPCs).
- Targeting CD70 through methods like antibody drug conjugates (ADCs) and engineered T or NK cells shows promising results in combating cells resistant to EGFR tyrosine kinase inhibitors, suggesting the potential for CD70 as a new treatment strategy.