Absorption of vaginal estrogen cream during sexual intercourse: a prospective, randomized, controlled trial.

Objective: To determine if intercourse changed serum estradiol levels in women using vaginal E2 cream or in their male partners.

Study Design: Prospective, randomized, placebo-controlled, crossover, blinded study of 10 postmenopausal women and their male sexual partners. Subjects were randomized to estradiol or placebo cream and intercourse, then crossed over after 7-14 days.