What about the children? Adult mental health practitioners' experiences and views of family-focused practice in Early Intervention Services.

Background: There is a significant risk of negative outcomes for families when a parent experiences serious mental illness. Family-focused practice (FFP) emphasises the "whole family" as the unit of care and has been found to improve outcomes for service users and their families. Despite its benefits, FFP is not routinely implemented in UK adult mental health services.

Parents who experience psychosis: A qualitative exploration.

Objectives: Psychosis can present parents with complex parenting challenges and significant adverse outcomes for parents and their children have been reported. However, remarkably little is known about how parenting is experienced by these parents. Therefore, this qualitative study aimed to understand the lived experiences of parents with psychosis, including how parenting support was experienced.

Evaluating laser-driven Bremsstrahlung radiation sources for imaging and analysis of nuclear waste packages.

A small scale sample nuclear waste package, consisting of a 28mm diameter uranium penny encased in grout, was imaged by absorption contrast radiography using a single pulse exposure from an X-ray source driven by a high-power laser. The Vulcan laser was used to deliver a focused pulse of photons to a tantalum foil, in order to generate a bright burst of highly penetrating X-rays (with energy >500keV), with a source size of <0.5mm.

A laser driven pulsed X-ray backscatter technique for enhanced penetrative imaging.

X-ray backscatter imaging can be used for a wide range of imaging applications, in particular for industrial inspection and portal security. Currently, the application of this imaging technique to the detection of landmines is limited due to the surrounding sand or soil strongly attenuating the 10s to 100s of keV X-rays required for backscatter imaging. Here, we introduce a new approach involving a 140 MeV short-pulse (< 100 fs) electron beam generated by laser wakefield acceleration to probe the sample, which produces Bremsstrahlung X-rays within the sample enabling greater depths to be imaged.

Energy coupling in short pulse laser solid interactions and its impact for space debris removal.

Significant advances have been made over the last decade to improve the performance, efficiency, and contrast of high peak and average power laser systems, driven by their use in a wide variety of fields, from the industrial to the scientific. As the contrast of the lasers has improved, interactions with contrasts of 10 are now routinely undertaken. At such high contrasts, there is negligible preplasma formation and the ionized surface layer created by subpicosecond-duration pulses typically forms a highly reflective "plasma mirror" capable of reflecting between 70% and 90% of the incident energy.

Perceived empowerment in people with a dual diagnosis of schizophrenia spectrum disorder and substance misuse.

Purpose: The aims of the present study were to validate a measure of empowerment in a British population of people with a dual diagnosis of schizophrenia and substance misuse and assess relationships between empowerment and other key outcomes.

Method: Patients participating in a large randomised control trial for Motivational Interviewing for Drug and Alcohol misuse in Schizophrenia or psychosis (MIDAS trial) completed measures of empowerment, symptoms, global functioning and substance use at baseline, 12- and 24-month follow-ups.

Results: A three factor model of empowerment: self-efficacy and control; power and anger; and activism provided the best fit of the data across all three time points.

Integrated motivational interviewing and cognitive-behavioural therapy for bipolar disorder with comorbid substance use.

Although comorbid substance use is a common problem in bipolar disorder, there has been little research into options for psychological therapy. Studies to date have concentrated on purely cognitive-behavioural approaches, which are not equipped to deal with the ambivalence to change exhibited by many towards therapy designed to change substance use. This paper provides the first report of an integrated psychological treatment approach for bipolar disorder with comorbid substance use.

The use of the repertory grid technique to examine staff beliefs about clients with dual diagnosis.

Aim: This paper reports a study exploring how individual psychiatric staff construes clients with psychosis who misuse substances.

Background: A dual diagnosis of substance misuse is common in clients with psychosis. Previous studies have suggested that psychiatric staff feel ill-equipped to work with these clients, and hold negative views of them, affecting client care and recovery.

Generation of terawatt pulses by use of optical parametric chirped pulse amplification.

Optical parametric chirped pulse amplifiers offer exciting prospects for generating new extremes in power, intensity, and pulse duration. An experiment is described that was used to investigate the operation of this scheme up to energies approaching a joule, as a step toward its implementation at the petawatt level. The results demonstrate an energy gain of 10(10) with an energy extraction efficiency of 20% and close to diffraction-limited performance.

A chip off the old block!

A 35 year old male presented 9 months after sustaining a penetrating injury to the neck with a false aneurysm of the common carotid artery (CCA). At exploration, a 5mm piece of granite was embedded in the posterior wall of the CCA with overlying endothelialisation. He was treated with segmental resection and an interposition vein graft.

Square core jacketed air-clad fiber.

We report the fabrication of a highly multi-mode square core jacketed air-clad fiber with a top-hat near-field intensity profile. Using this fiber to deliver Q-switched pulses at 1 mum we have successfully produced square shaped ablation marks in indium tin oxide (ITO) without the use of complex beam shaping optics.

Distress in Parkinson's disease: contributions of disease factors and metacognitive style.

Research has suggested that the high levels of depression and anxiety observed in Parkinson's disease are a primary consequence of its pathophysiology. This study aimed to test the hypothesis that a psychological factor, metacognitive style, is significantly associated with distress, independent of previously identified disease-related risk factors. Distress, metacognitive style and disease factors were assessed in 44 people with a diagnosis of Parkinson's disease.

Measurements of relativistic self-phase-modulation in plasma.

We report the first systematic observations of relativistic self-phase-modulation (RSPM) due to the interaction of a high intensity laser pulse with plasma. The plasma was produced in front of a solid target by the prepulse of a 100 TW laser beam. RSPM was observed by monitoring the spectrum of the harmonics generated by the intense laser pulse during the interaction.

Dynamics of the critical surface in high-intensity laser-solid interactions: modulation of the XUV harmonic spectra.

The generation of harmonics from the interaction of an intense (I>or=10(18) W cm(-2)) laser with a solid surface is investigated. Modulation of the harmonic emission spectrum with a periodicity of 2 to 4 harmonics is observed at higher laser intensities. A similar modulation is predicted by a particle-in-cell simulation.

Observation of a hot high-current electron beam from a self-modulated laser wakefield accelerator.

A highly relativistic electron beam produced by a 50 TW laser-plasma accelerator has been characterized by photonuclear techniques. The beam has large divergence that increases with plasma density. The electron yield also increases with plasma density and reaches up to 4x10(11) electrons ( >10 MeV), with beam current approaching the Alfvén limit.

Effect of the plasma density scale length on the direction of fast electrons in relativistic laser-solid interactions.

The angular distribution of bremsstrahlung gamma rays produced by fast electrons accelerated in relativistic laser-solid interaction has been studied by photoneutron activation in copper. We show that the gamma-ray beam moves from the target normal to the direction of the k(laser) vector as the scale length is increased. Similar behavior is found also in 2D particle-in-cell simulations.

Photonuclear physics when a multiterawatt laser pulse interacts with solid targets.

When a laser pulse of intensity 10(19) W cm(-2) interacts with solid targets, electrons of energies of some tens of MeV are produced. In a tantalum target, the electrons generate an intense highly directional gamma-ray beam that can be used to carry out photonuclear reactions. The isotopes 11C, 38K, (62,64)Cu, 63Zn, 106Ag, 140Pr, and 180Ta have been produced by (gamma,n) reactions using the VULCAN laser beam.

Drug education: a review of British Government policy and evidence on effectiveness.

British Government policy on drugs primary prevention is outlined and principal recommendations are identified. The review is organized under the four main providers: police, teachers, peers and parents. Current methods are reviewed within a British policy framework with a focus on British programmes which have been evaluated.

The development and evaluation of a brief risk screening instrument for the psychiatric inpatient setting.

This paper reports on the development and evaluation of a risk screening instrument (RSI) intended for use by nursing staff on general acute psychiatric admission wards. The RSI comprised six questions concerning patient status on admission (e.g.

Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians.

Genetic factors may be of importance in determining inter-individual susceptibility to alcoholic liver disease (ALD). Among the candidate genes which have been considered to be important are those which code for enzymes involved in alcohol metabolism. Cytochrome P4502E1 (CYP2E1) metabolizes alcohol to acetaldehyde and the hydroxyethyl radical, and is also inducible by alcohol.

Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients. Assessment by radiometric HPLC.

Idiosyncratic hypersensitivity reactions with carbamazepine have been postulated to be due to a deficiency of microsomal epoxide hydrolase (HYL1), although this is based on indirect evidence. Using 3H-cis stilbene oxide (0.5 Ci/mmol) as a substrate, we have developed a radiometric HPLC assay sensitive enough to measure the kinetic parameters of HYL1 in lymphocytes.

Elimination of interference effects from photoinduced-transmission decay curves of thin silicon films.

The effects of interference on the photoinduced-absorption signals of thin absorbing films have been studied by recording the picosecond photoinduced-absorption decay curves of an amorphous and a polycrystalline silicon film and applying various probe-beam wavelengths and angles of incidence. The normalized decay curves measured at close to normal incidence have been found to depend strongly on the probe-beam wavelength. By contrast the decay curves obtained at the Brewster angle of incidence have shown a satisfactory coincidence.

Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy.

1. In order to determine whether carbamazepine is an inducer of lymphocyte microsomal epoxide hydrolase, the activity of the enzyme has been measured in the lymphocytes of 40 patients on continuous drug therapy using [3H]-cis stilbene oxide as a substrate. 2.