Extent of the decrease of 28-day case fatality of hospitalized patients with acute myocardial infarction over 22 years: epidemiological versus clinical view: the MONICA/KORA Augsburg infarction registry.

Background: No data exist regarding time trends of 28-day case fatality (CF) of patients with presumed acute myocardial infarction (AMI) using epidemiological criteria, clinical criteria, and AMI classification after validation of presumed in-hospital AMI-related deaths (gold-standard criteria).

Methods And Results: From 1985 to 2004, we prospectively examined all 9210 AMI patients consecutively hospitalized in a large teaching hospital by using a broad epidemiological AMI definition (WHO-MONICA). Twenty-eight-day CF decreased significantly from 32% in 1985-1986 to 18% in 2003-2004, mostly because of a reduction in early deaths (<24 hours).

Differential impact of admission C-reactive protein levels on 28-day mortality risk in patients with ST-elevation versus non-ST-elevation myocardial infarction (from the Monitoring Trends and Determinants on Cardiovascular Diseases [MONICA]/Cooperative Health Research in the Region of Augsburg [KORA] Augsburg Myocardial Infarction Registry).

The present study investigated the association between C-reactive protein (CRP) on admission independently and in combination with troponin and short-term prognosis in an unselected sample of patients with acute myocardial infarction (AMI) from the community. The study population consisted of 1,646 patients aged 25 to 74 years who were consecutively hospitalized with AMI within 12 hours after symptom onset. They were divided into the 2 groups of CRP positive (n = 919) or CRP negative (n = 727) with respect to admission CRP (cutoff < or =0.

Characteristics and outcome of patients with acute myocardial infarction according to presenting electrocardiogram (from the MONICA/KORA Augsburg Myocardial Infarction--Registry).

Acute myocardial infarctions (AMIs) are categorized according to presenting electrocardiography into ST-elevation (STE), non-STE, and bundle branch block AMIs. Data on the characteristics and risks of these categories originate mainly from voluntary registries or clinical trials and may be hampered by selection and information bias. This study evaluated these different categories, with the additional differentiation of non-STE AMIs into ST-depression (STD) AMIs and those with nonspecific electrocardiographic signs (no-ST) in an unselected cohort.