Publications by authors named "Allister Gibbons"
This study aims to compare the levels of intrinsic protein disorder within the human lens and zonule proteomes and investigate the role of aging as a potential influencing factor on disorder levels. A cross-sectional proteomic analysis was employed, utilizing a dataset of 1466 proteins derived from the lens and zonule proteomes previously published by Wang et al. and De Maria et al.
View Article and Find Full Text PDFPurpose: To assess the cost-utility of prophylactic laser peripheral iridotomy (LPI) for primary angle closure (PAC) suspects (PACS).
Design: Economic evaluation.
Methods: Our Markov model randomized PACS eyes to LPI or observation for 40 one-year cycles (100,000 iterations per strategy).
The present report describes a case of semi-autologous corneal transplantation with bilateral surgery using two operating microscopes simultaneously. An 86-year-old man with history of six prior failed penetrating keratoplasties in his right eye presented with decreased vision. His other eye was deeply amblyopic but had a clear 30-year-old Castroviejo-square graft with an endothelial cell count of 803 cells/mm.
View Article and Find Full Text PDFTo review the recent literature regarding risk factors for cataract formation after vitrectomy, the challenges and management strategies for anterior segment surgeons when facing post-vitrectomy cataract surgery, and the visual outcomes of patients undergoing post-vitrectomy cataract surgery. Cataract surgery after vitrectomy can be safely performed to significantly improve the visual outcome in most post-vitrectomy patients, although final visual acuity is primarily limited by the patient’s underlying vitreoretinal pathology.
View Article and Find Full Text PDFPurpose:: The purpose of this article is to discuss the early- and late-onset corneal complications that can occur following vitreoretinal surgery.
Methods:: A systematic review of the literature was conducted using PubMed and Google Scholar databases. Articles detailing the clinical findings and the associations between surgical techniques, irrigating solutions, and microsurgical instruments used for vitreoretinal surgery and postoperative corneal complications were included in this review.
DESCEMET STRIPPING AUTOMATED ENDOTHELIAL KERATOPLASTY GRAFT IN-THE-BAG POSTERIOR DISLOCATION.
Retin Cases Brief Rep
November 2023
Purpose: The purpose of this report was to describe a case of a dislocated Descemet stripping automated endothelial keratoplasty graft retained in-the-bag removed with pars plana vitrectomy (PPV).
Methods: This was a case report.
Results: A 69-year-old pseudophakic man who underwent a repeat Descemet stripping automated endothelial keratoplasty due to bullous keratopathy in the setting of multiple previous ocular surgeries presented with a vision of counting fingers.
Purpose: To compare three automated devices for measuring the horizontal corneal diameter (white to white [WTW]).
Methods: In 65 eyes of 38 patients, the WTW distance was measured independently by three examiners using the following techniques: Orbscan IIz tomography system (Bausch & Lomb), IOLMaster 700 (Carl Zeiss Meditec), and OPD Scan III (NIDEK). We tested for systematic differences in measurements and estimated the limits of agreement (LoA) using linear mixed-effects models.
Endothelial keratoplasty is the most commonly performed type of corneal transplant in the United States, currently accounting for 60% of total grafts. The anterior segment complications are well documented; however, the posterior segment complications may not be as familiar to the anterior segment surgeon. These include endophthalmitis, cystoid macular edema (CME), choroidal detachment, graft dislocation to the posterior segment, and retinal detachment.
View Article and Find Full Text PDFPurpose: To evaluate the cost-utility of treatment for macular edema in central retinal vein occlusion (CRVO) using intravitreal injections of the anti-vascular endothelial growth factor (VEGF) agents bevacizumab, ranibizumab, and aflibercept.
Design: Decision analysis model of cost-utility.
Participants: Data from study participants in the Lucentis, Eylea, Avastin in Vein Occlusion (LEAVO) study.
Phacoemulsification in the Setting of Corneal Endotheliopathies: A Review.
Int Ophthalmol Clin
April 2021
With the evolution of endothelial keratoplasty, surgical approaches in patient with cataracts and coexisting corneal endotheliopathies have also changed. This article aims to review the factors that determine proper procedure selection, preoperative planning, and surgical modifications during phacoemulsification in order to optimize visual outcomes and avoid surgical pitfalls. The selection of either simultaneous cataract surgery and keratoplasty or staged procedures depends on the patient’s history and clinical exam, desired refractive outcomes, the surgeon’s expertise, and individual preferences.
View Article and Find Full Text PDFPurpose: To determine the cost effectiveness of an adjunctive screening OCT during the preoperative evaluation of a patient considering cataract surgery with a multifocal intraocular lens (IOL) implantation.
Design: Cost-effectiveness analysis.
Participants: A 67-year-old man with 20/60 vision undergoing evaluation for first-eye cataract surgery.
Purpose: To evaluate the cost-effectiveness of supplementing hypothermic cold storage media (CSM) with antifungal therapy.
Design: Cost-effectiveness analysis (CEA).
Participant: Base case of a patient with Fuch's endothelial dystrophy undergoing a first eye keratoplasty.
Aim: To develop a model to evaluate the cost-utility of choroidal nevi monitoring recommendations with varying clinical risk factors.
Methods: A Markov model was created to evaluate the cost-utility in cost per quality-adjusted life-year ($/QALY) for monitoring patients with choroidal nevus. This probabilistic model was applied both to a hypothetically monitored and unmonitored group of patients beginning at different ages and with varying clinical risk factors of the nevus.
Purpose: To identify the incidence of endophthalmitis and visual outcomes in eyes with Boston type 1 keratoprosthesis combined with pars plana vitrectomy and silicone oil insertion (KPro + PPV + SOI) as compared to eyes receiving Boston type 1 keratoprosthesis (KPro) alone.
Patients And Methods: Retrospective chart review of 29 eyes of 27 patients with KPro having at least 12-month follow-up. Thirteen of these eyes had hypotony and/or retinal detachment in addition to corneal pathology and thus received KPro + PPV + SOI.
Purpose: To determine the cost-effectiveness of Descemet's membrane endothelial keratoplasty (DMEK) compared with Descemet's stripping automated endothelial keratoplasty (DSAEK) in the United States.
Design: Cost-effectiveness analysis in a surgical center in the United States.
Participants: Binocular adult patient undergoing endothelial keratoplasty.
Purpose: To evaluate the epidemiology of persistent postsurgical pain (PPP) manifesting as dry eye (DE)-like symptoms 6 months after surgery.
Methods: This single-center study included 119 individuals whose cataract surgeries were performed by a single surgeon at the Bascom Palmer Eye Institute and who agreed to participate in a phone survey 6 months after surgery. Patients were divided into 2 groups: the PPP group was defined as those with a Dry Eye Questionnaire-5 score ≥6 and without PPP as those with a Dry Eye Questionnaire-5 score <6 at 6 months after cataract surgery.
Purpose: To determine the cost-effectiveness of intracameral moxifloxacin compared with traditional antibiotic prophylaxis in preventing endophthalmitis after cataract surgery.
Setting: Theoretical surgical center in the United States.
Design: Evaluation of technology.
Purpose Of Review: To summarize the recent advances in the prevention of herpes zoster. The recent Food and Drug Administration (FDA) approval of an adjuvanted subunit vaccine may have a significant impact on the prevention of herpes zoster ophthalmicus.
Recent Findings: There are currently two commercially available vaccines for the prevention of herpes zoster: a live-attenuated vaccine and a new recombinant subunit vaccine.
Purpose: To determine the indications, long-term clinical and visual outcomes, and complications of the aphakic snap-on type I Boston keratoprosthesis (KPro).
Design: Retrospective, non-comparative case series.
Methods: Forty-five eyes of 43 patients with type I aphakic snap-on KPros with at least 1 year of follow-up were included.
Purpose: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s).
Design: Retrospective, interventional case series.
Methods: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20%-50%) for chronic surface disease were analyzed.
Purpose: Stenotrophomonas maltophilia, an uncommon cause of infectious keratitis, is difficult to treat because of its resistance to multiple antibiotics. The purpose of this study is to describe the clinical features, antibiotic susceptibility profile, and outcomes of S. maltophilia keratitis.
View Article and Find Full Text PDFPurpose: To determine the impact of total pars plana vitrectomies (PPVs) with peripheral shaving of the vitreous base on the rates of postoperative complications in patients with aphakic, snap-on type I Boston keratoprostheses (KPros).
Design: Retrospective, consecutive case series.
Participants: A total of 48 eyes in 46 patients with implantation of aphakic, snap-on type 1 Boston KPros performed at a tertiary care facility between January 1, 2007, and December 31, 2013, were included.
Purpose: To evaluate the ocular surface parameters that could predict patient satisfaction after single application of vectored thermal pulsation (VTP).
Methods: This is a retrospective interventional case series; it included consecutive patients who underwent bilateral VTP for management of symptomatic meibomian gland dysfunction (MGD). Patients received a full ocular surface evaluation.
Purpose: To report a series of patients who developed corneal toxicity after exposure to aquarium coral palytoxin.
Design: Multicenter retrospective case series.
Methods: Retrospective review.