Publications by authors named "Allison Tomasino"
Late effects of total- or partial-body irradiation include chronic kidney injury (CKI), which increases morbidity and mortality. Glomerular filtration rate (GFR) is the gold standard measure of kidney function. Renal function markers, such as blood urea nitrogen (BUN) and serum creatinine (Cr), may not be higher than reference ranges until 50% or more of nephrons are affected.
View Article and Find Full Text PDFBackground: Symptomatic neuromata are a common indication for revision surgery following amputation. Previously described treatments, including traction neurectomy, nerve transposition, targeted muscle re-innervation, and nerve capping, have provided inconsistent results or are technically challenging. Prior research using acellular nerve allografts (ANA) has shown controlled termination of axonal regrowth in long grafts.
View Article and Find Full Text PDFA pressing clinical need exists for 63% to 65% of combat-wounded service members and 11% to 20% of civilians who develop heterotopic ossification (HO) after blast-related extremity injury and traumatic injuries, respectively. The mammalian target of rapamycin pathway is a central cellular sensor of injury. We evaluated the prophylactic effects of rapamycin, a selective inhibitor of mammalian target of rapamycin signaling, on HO formation in a rat model of blast-related, polytraumatic extremity injury.
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- Heterotopic ossification (HO) is a condition that commonly affects wounded service members, especially after severe injuries like blasts and amputations, and there's currently no effective preventative treatment.
- The study examined the drug Palovarotene in a rodent model, finding it reduced inflammation and bone formation related to HO, markedly decreasing specific inflammatory cytokines and progenitor cell activity.
- Additionally, Raman spectroscopy proved effective at detecting early signs of HO formation before visible changes occur, suggesting potential for earlier diagnosis and intervention.
Heterotopic ossification (HO) is a debilitating sequela of high-energy injuries. It frequently requires surgical excision once symptomatic and there is no practical prophylaxis for combat-injured patients. In this study, we examined the effect of local vancomycin powder on HO formation in a small animal model of blast-related, post-traumatic HO.
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- * The study tested the retinoic acid receptor γ agonist Palovarotene in a rat model of trauma-induced HO created by blast injuries, revealing that it significantly reduced HO by 50-60% and altered the development of ectopic bone and related tissues.
- * Although Palovarotene effectively inhibited HO, it also showed moderate negative effects on wound healing, indicating the need for careful consideration of dosing and timing in potential treatments.