Publications by authors named "Allison T Hands"
We report the strain-induced [2 + 2] cycloadditions of cyclic allenes for the assembly of highly substituted cyclobutanes. By judicious choice of trapping agent, complex scaffolds bearing heteroatoms, fused rings, contiguous stereocenters, spirocycles, and quaternary centers are ultimately accessible. Moreover, we show that the resulting cycloadducts can undergo thermal isomerization.
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- Identifying chemical regulators in biological pathways is a slow and costly process, usually involving extensive testing of potential small molecules tailored to specific diseases.
- The authors propose a virtual, profile-based screening method that leverages public cell image data from the Cell Painting assay to identify compounds linked to biological pathways without needing extensive customization.
- Their approach successfully identified known small-molecule regulators in a substantial percentage of cases and discovered new compounds relevant to specific genes, demonstrating potential to streamline therapeutic compound discovery.