Publications by authors named "Allison Sams"
Importance: Recently, the benefit of adding daratumumab to the proteasome inhibitor-based, 3-drug combination of bortezomib, lenalidomide, and dexamethasone for patients with newly diagnosed multiple myeloma who underwent high-dose melphalan chemotherapy and autologous hemopoietic cell transplant was assessed. Here, we examine the addition of daratumumab to the second-generation proteasome inhibitor-based, 3-drug combination of carfilzomib, lenalidomide, and dexamethasone.
Objective: To assess the safety and effectiveness of carfilzomib-lenalidomide-dexamethasone-daratumumab combination therapy for patients with newly diagnosed multiple myeloma, in the absence of high-dose melphalan chemotherapy and autologous hemopoietic cell transplant.
Article Synopsis
- Systemic immunoglobulin light-chain (AL) amyloidosis is a rare disorder caused by misfolded proteins from plasma cells, resulting in deposits that affect various organs.
- The symptoms are often vague and can resemble other common diseases, leading to delays in diagnosis, which negatively impacts patient outcomes, especially in cases involving the heart.
- Increased awareness among healthcare practitioners of the key symptoms and the latest diagnostic tests can help identify AL amyloidosis earlier, ultimately improving patient care and outcomes.
Radioiodine (present mostly as I) is difficult to remove from waste streams or contaminated groundwater because it tends to exist as multiple anionic species (i.e., iodide (I), iodate (IO) and organo-iodide) that do not bind to minerals or synthetic materials.
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