Publications by authors named "Allison N Nau"
Background: Each monoclonal antibody light chain associated with AL amyloidosis has a unique sequence. Defining how these sequences drive amyloid deposition could facilitate faster diagnosis and lead to new treatments.
Methods: Light chain sequences are collected in the AL-Base repository.
Background: Each monoclonal antibody light chain associated with AL amyloidosis has a unique sequence. Defining how these sequences lead to amyloid deposition could facilitate faster diagnosis and lead to new treatments.
Methods: Light chain sequences are collected in the Boston University AL-Base repository.
Article Synopsis
- Coronary artery disease (CAD) is now recognized not just as a lipid disorder but also as a condition marked by chronic inflammation, particularly involving immune cell activity in atherosclerotic plaques.
- Researchers employed single-cell technology to explore the immune microenvironment of coronary plaques at various maturity stages, revealing a significant presence of activated αβ T cells alongside macrophages.
- Findings indicated these T cells, which show clonal expansion and specificity to several viral epitopes, are likely involved in autoimmune responses contributing to the disease, with some exhibiting pro-inflammatory properties that may further encourage plaque progression.
For more than five years, high-dimensional mass cytometry has been employed to study immunology. However, these studies have typically been performed in one laboratory on one or few instruments. We present the results of a six-center study using healthy control human peripheral blood mononuclear cells (PBMCs) and commercially available reagents to test the intra-site and inter-site variation of mass cytometers and operators.
View Article and Find Full Text PDF