Evaluation of cost savings to a state Medicaid program following a sertraline tablet-splitting program.

Objectives: To evaluate the economic impact of implementing a sertraline (Zoloft--Pfizer) tablet-splitting program on the Nebraska Medicaid program based on the change in total and per-member-per-month (PMPM) prescription drug costs and to identify any real or perceived problems with tablet splitting using switches among selective serotonin reuptake inhibitors (SSRIs) as a proxy indicator.

Design: Retrospective study of prescription claims before and after the tablet-splitting program was implemented.

Setting: Nebraska Medicaid.