Publications by authors named "Allison Koch"
Central corneal thickness (CCT) is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG). The present study uses the BXD Recombinant Inbred (RI) strains to identify novel quantitative trait loci (QTLs) modulating CCT in the mouse with the potential of identifying a molecular link between CCT and risk of developing POAG. The BXD RI strain set was used to define mammalian genomic loci modulating CCT, with a total of 818 corneas measured from 61 BXD RI strains (between 60-100 days of age).
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- Exfoliation syndrome (XFS) is a common cause of a type of eye disease called open-angle glaucoma.
- Researchers studied the DNA of nearly 1,500 people with XFS and compared it to over 1,100 healthy people from Japan, and then looked at even more data from around the world.
- They found a new gene that seems to increase the chances of getting XFS and confirmed another gene that behaves differently in people from different backgrounds.
The products of five structural genes and two regulatory genes of the qa gene cluster of Neurospora crassa control the metabolism of quinic acid (QA) as a carbon source. A detailed genetic network model of this metabolic process has been reported. This investigation is designed to expand the current model of the QA reaction network.
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