Phage-Related Ribosomal Proteases (Prps): Discovery, Bioinformatics, and Structural Analysis.

Many new antimicrobials are analogs of existing drugs, sharing the same targets and mechanisms of action. New antibiotic targets are critically needed to combat the growing threat of antimicrobial-resistant bacteria. Phage-related ribosomal proteases (Prps) are a recently structurally characterized antibiotic target found in pathogens such as , , and These bacteria encode an N-terminal extension on their ribosomal protein L27 that is not present in other bacteria.