Publications by authors named "Allison Franklin"
Article Synopsis
- Dravet Syndrome (DS) is a severe epilepsy in children that increases the risk of Sudden Unexpected Death in Epilepsy (SUDEP), often linked to mutations in a specific gene affecting both the brain and heart.
- Research using a DS mouse model revealed significant sex-specific changes in cardiac mitochondrial function, with male mice showing reduced respiratory capacity and increased vulnerability to arrhythmias.
- The study highlights that males are more susceptible to these cardiac issues compared to females, suggesting that therapeutic approaches for SUDEP risk in DS should take sex differences into account.
plays essential roles in the heart, where it encodes β-subunits that serve as modifiers of gene expression, cell surface channel activity, and cardiac conductivity. Reduced β function is linked to electrical instability in various diseases with cardiac manifestations and increased susceptibility to arrhythmias. Recently, we demonstrated that loss of in mice leads to compromised mitochondria energetics and reactive oxygen species (ROS) production.
View Article and Find Full Text PDFWe determined the demographic, health, functional, and satisfaction factors related to lower-limb prosthesis or wheelchair use among veterans with lower-limb amputation. Forty-two veterans were recruited from the 20th National Disabled Veterans Winter Sports Clinic and the 26th National Veterans Wheelchair Games. Participants were at least 18 years of age, had a lower-limb amputation, and were either prosthesis or wheelchair users.
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