Publications by authors named "Allison Carol Nugent"
Altered function in the limbic-cortical-striatial-pallidal-thalamic (LCSPT) circuit has been implicated in the pathophysiology of major depressive disorder (MDD). This study evaluated volumetric differences in subcortical volumes between depressed subjects with MDD (N=142), subjects with MDD in remission (N=72), and healthy controls (N=169). Participants underwent magnetic resonance imaging (MRI) scanning, and subcortical volumes were extracted using FMRIB's Integrated Registration and Segmentation Tool (FIRST), University of Oxford, UK.
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- Research shows that major depressive disorder (MDD) affects autonomic control, specifically heart rate variability (HRV).
- In this study, researchers compared brain activity and HRV in medically healthy women with MDD and healthy controls while performing stressful tasks.
- The findings revealed differences in brain blood flow patterns and HRV correlations between the two groups, particularly in the orbital cortices, highlighting their roles in autonomic control and MDD's pathophysiology.