Publications by authors named "Allison Barrie"
Background: High-risk human papillomavirus (hrHPV) testing has become integral in the screening and treatment protocols for cervical neoplasia. Stand-alone HPV testing is advocated as a screening tool for cervical neoplasia. However, negative hrHPV tests with diagnosis of high-grade squamous intraepithelial lesion or worse (≥HSIL) have been reported.
View Article and Find Full Text PDFArticle Synopsis
- High-grade serous ovarian cancer (HGSOC) is a deadly cancer type known for a lack of immune response, indicated by the low presence of tumor infiltrating lymphocytes (TILs) and poor responses to immunotherapy.
- Research found that active FAK (focal adhesion kinase), which is linked to poor survival rates and prevalent in about 70% of HGSOC cases, correlates with reduced levels of TILs and increased expression of immune checkpoint ligands like CD155.
- Using a mouse model, the study revealed that inhibiting FAK not only reduced tumor size and associated immune responses but also enhanced the effectiveness of combining FAK inhibitors with TIGIT-blocking antibodies, suggesting a new immunotherapy strategy for H
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence. Stem phenotypes involving Wnt-β-catenin, aldehyde dehydrogenase activities, intrinsic platinum resistance, and tumorsphere formation are here associated with spontaneous gains in , and (KMF) genes in a new aggressive murine model of ovarian cancer. Adhesion-independent FAK signaling sustained KMF and human tumorsphere proliferation as well as resistance to cisplatin cytotoxicity.
View Article and Find Full Text PDFArticle Synopsis
- Ovarian cancer is a significant health issue, being the fifth leading cause of cancer deaths in women, with late-stage disease characterized by tumor spheroids that resist environmental stress.
- Rgnef, a guanine nucleotide exchange factor, is found to be elevated in late-stage ovarian cancer and is linked to poorer patient prognosis, as its increased levels correlate with decreased survival rates, while its loss is associated with better outcomes.
- Research indicates that Rgnef is crucial for the formation of ovarian spheroids and tumor growth, and it supports an antioxidant gene signature that protects cancer cells from oxidative stress, highlighting its potential role in cancer progression and therapy.
•Complimentary alternative medicine use is common in women with gynecologic cancers.•Cannabinoid receptors are potential therapeutic targets in ovarian cancer.•Communication with patients is critical regarding use of alternative therapies.
View Article and Find Full Text PDFObjective: Describe clinical characteristics and risk reducing strategies utilized among women with a BRCA mutation who lived to age 75 and above.
Methods: A retrospective study of women with BRCA mutations identified from 1995 to 2015 in a California health care system. From a database of 1189 women, 69 participants were identified who lived to age 75 or older.
Study Objective: To determine the association between resident involvement and operative time for minimally invasive surgery (MIS) for endometrial cancer.
Design: A retrospective cohort study (Canadian Task Force classification II-2).
Setting: An integrated health care system in Northern California.
Study Objective: To compare intraoperative and postoperative surgical complications and outcomes between robotic-assisted and laparoscopic surgical management of endometrial cancer using a standardized classification system.
Design: A retrospective cohort study (Canadian Task Force classification II-2).
Setting: An integrated health care system in Northern California.
Objective: To determine the rate of venous thromboembolism (VTE) among women undergoing minimally invasive surgery (MIS) for endometrial cancer.
Methods: Women undergoing robotic or laparoscopic hysterectomy for endometrial carcinoma or complex hyperplasia with atypia were identified between January 2009 and 2014 in a community based health care system. Patient data including age, race, cancer stage, grade, procedure type, length of hospital stay, use of prophylaxis, and diagnosis of VTE were collected retrospectively.