Demonstrating removal credits for contaminants of emerging concern in recycled water through a reverse osmosis barrier-A predictive framework.

The performance of individual reverse osmosis (RO) systems varies significantly with different contaminants of emerging concern (CECs). As such, log reduction values (LRVs) of the concentration of these chemicals cannot be arbitrarily credited in water treatment and water recycling. This study looks to present an approach to the management of chemical risks by providing a systematic validation of RO barrier performance with respect to LRV credits for various classes of CECs.

Factors affecting clinical pharmacist decision-making when reviewing and prescribing z-drugs in primary care: a qualitative interview study.

Background: Z-drugs (zopiclone, zolpidem and zaleplon) are drugs with dependence forming characteristics licensed for the short-term management of insomnia. Patients regularly prescribed z-drugs are candidates for 'structured medication reviews', routinely delivered by pharmacists employed in general practice or primary care networks in England.

Aim: To understand the factors that affect pharmacist decision-making when reviewing and prescribing z-drugs in primary care.

Sub-ppm determination of in solution by UV-vis high-performance liquid chromatography through solid phase extraction.

This study investigated a novel and sensitive analytical method based on a simple heat-based derivatization using 3-bromoacetyl coumarin as the reagent and analysis with a HPLC-UV system or just a UV-vis spectrometer to allow the sub-ppm determination of PFCAs in water solution with the potential for utilization in simple laboratories and field laboratory scenarios. A Strata-X-AW cartridge was used for the solid phase extraction (SPE) procedure and higher than 98% recoveries were obtained. The derivatization condition showed that a high efficiency of peak separation was obtained with obviously different retention time among various PFCAs derivatives using HPLC-UV analysis.

A chemical credit framework to predict the removal performance of organic chemicals of concern from water through an ozonation process.

Ozonation is an effective barrier for removing a wide spectrum of organic Chemicals of Concern (CoC) in a water treatment process. In this study, bench- and full-scale tests were conducted on a secondary treated effluent at the Eastern Treatment Plant (ETP) of Melbourne Water to probe the performance of ozonation in removing CoC in a wastewater discharge. From the secondary treated effluent as the feed to the ozone process, 58 organic chemicals were measured out of a possible 949 compounds by using the AIQS-DB analytical method.

In situ calibration of passive sampling methods for urban micropollutants using targeted multiresidue GC and LC screening systems.

In this study, Chemcatcher (CC) and Polar Organic Chemical Integrative Samplers (POCIS) passive samplers were chosen to investigate trace organic chemical residues in urban streams of the megacity of Sydney, Australia. In situ calibration with these passive samplers investigated 1392 organic chemicals. Six sets of CC passive samplers fitted with SDB-XC or SDB-RPS disks and six POCIS containing Oasis HLB sorbent were deployed at three sites.

Community pharmacists' experiences of working during lockdown.

Background: Transmission of the novel coronavirus strain, SARS-CoV-2, caused many health services to reach crisis points worldwide. As infection rates rose, many countries implemented 'lockdown' periods where only essential services could remain open; this included community pharmacies in the UK. This study retrospectively explores the experiences of community pharmacists during the first lockdown period of the pandemic in the UK, helping us to learn for the future if another pandemic were to arise.

Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice.

For many pharmacy students in the United Kingdom there are few opportunities during undergraduate education to learn, or be exposed to, different ways of dealing with ethical and professional dilemmas in real life practice. This study aimed to explore the experiences of graduates during their pre-registration year and early practice (up to two years post-qualification) on their perceived preparedness to make professional decisions when faced with problems or dilemmas once in practice. Semi-structured interviews were undertaken with preregistration trainees and early careers pharmacists (up to two years qualified).

Pharmacy graduates' perceived impact of long-term undergraduate use of an ethical decision-support tool on their early practice.

Introduction: Values-based practice is an important concept within healthcare decision-making that sits alongside evidence-based practice. Values Exchange (Vx) (http://www.vxcommunity.

Transcriptome-wide changes associated with the reproductive behaviour of male guppies exposed to 17α-ethinyl estradiol.

Although many pharmaceutical compounds (and their metabolites) can induce harmful impacts at the molecular, physiological and behavioural levels, their underlying mechanistic associations have remained largely unexplored. Here, we utilized RNA-Seq to build a whole brain transcriptome profile to examine the impact of a common endocrine disrupting pharmaceutical (17α-ethinyl estradiol, EE2) on reproductive behaviour in wild guppies (Poecilia reticulata). Specifically, we annotated 16,791 coding transcripts in whole brain tissue in relation to the courtship behaviour (i.

Occurrence of perfluoroalkyl substances in selected Victorian rivers and estuaries: An historical snapshot.

This reconnaissance study was undertaken in 2012 to examine the occurrence of common perfluoroalkyl substances (PFAS), including perfluoroalkyl sulphonic acids and perfluoroalkyl carboxylic acids in rivers and estuaries in Port Philip Bay, Victoria, Australia. In total, 19 PFAS were screened in grab samples of water using a combination of solid phase extraction and liquid chromatography - mass spectrometry measurement techniques. Eighteen of the PFAS screened were observed in samples.

Glyphosate and aminomethylphosphonic acid (AMPA) are commonly found in urban streams and wetlands of Melbourne, Australia.

Glyphosate is the most widely-used pesticide for weed control in agriculture and in urban and residential areas. This is the first study to quantify glyphosate and AMPA levels in surface water in Australia from different land uses. Glyphosate and AMPA was measured in surface water from 10 rural streams, 30 urban stormwater wetlands and 9 urban streams located in and around the city of Melbourne, Australia on five occasions between October 2017 and February 2018.

A critical control point approach to the removal of chemicals of concern from water for reuse.

The reuse of water in a range of potable and non-potable applications is an important factor in the augmentation of water supply and in improving water security and productivity worldwide. A key hindrance to the reuse of water is the cost of compliance testing and process validation associated with ensuring that pathogen and chemicals in the feedwater are removed to a level that ensures no acute or chronic health and/or environmental effects. The critical control point (CCP) approach is well established and widely adopted by water utilities to provide an operational and risk management framework for the removal of pathogens in the treatment system.

The endocrine disruptor, 17α-ethinyl estradiol, alters male mate choice in a freshwater fish.

Among the handful of studies on the behavioural effects of endocrine disrupting chemicals (EDCs), only a few have set out to disentangle the mechanisms underpinning behavioural changes. In fish, previous studies have shown that both visual and chemical cues play an important role in mate choice. As such, contaminant-induced changes in either transmission or perception of mate choice cues could have direct implications for individual's fitness.

Wastewater recycling in Antarctica: Performance assessment of an advanced water treatment plant in removing trace organic chemicals.

The Australian Antarctic Division (AAD) operates Australia's Davis Station in the Antarctic. In 2005, Davis Station's wastewater treatment plant failed and since then untreated, macerated effluent has been discharged to the ocean. The objectives of this study were to determine whether an advanced water treatment plant (AWTP) commissioned by the AAD and featuring a multi-barrier process involving ozonation, ceramic microfiltration, biologically activated carbon filtration, reverse osmosis, ultraviolet disinfection and chlorination was capable of producing potable water and a non-toxic brine concentrate that can be discharged with minimal environmental impact.

Students views of an online ethical decision-support tool.

Background And Purpose: Ethical reasoning is a key skill that must be developed during the undergraduate pharmacy course to prepare students for ethical decision-making in future practice as pharmacy professionals. In this initial study, we sought and documented the views of pharmacy students at a United Kingdom (UK) university on the use of Values Exchangeâ„¢ (Vx), an online ethical decision-support tool.

Educational Activity And Setting: Students deliberated on up to three ethical case scenarios every academic year using the tool.

Occurrence and assessment of the risk of ultraviolet filters and light stabilizers in Victorian estuaries.

This reconnaissance study was undertaken to examine the occurrence of common ultraviolet filters (UVF) and light stabilizers (UVLS), and preservatives in four different estuaries in Port Philip Bay, Victoria, for the first time. In total, 11 UV filters, 10 UV stabilizers, 12 preservatives and a metabolite, and one fragrance were screened in grab samples of water and sediment using a combination of solid phase extraction and gas and liquid chromatography mass spectrometry measurement techniques. In that context, 16 of the UVF and UVLS and 5 of the preservatives screened were observed in water and/or sediment samples.

The agricultural contaminant 17β-trenbolone disrupts male-male competition in the guppy (Poecilia reticulata).

Despite a growing literature highlighting the potential impact of human-induced environmental change on mechanisms of sexual selection, relatively little is known about the effects of chemical pollutants on male-male competition. One class of environmental pollutant likely to impact male competitive interactions is the endocrine-disrupting chemicals (EDCs), a large and heterogeneous group of chemical contaminants with the potential to influence morphology, physiology and behaviour at minute concentrations. One EDC of increasing concern is the synthetic, androgenic steroid 17β-trenbolone, which is used globally to promote growth in beef cattle.

Characterisation of the transcriptome of male and female wild-type guppy brains with RNA-Seq and consequences of exposure to the pharmaceutical pollutant, 17α-ethinyl estradiol.

Waterways are increasingly being contaminated by chemical compounds that can disrupt the endocrinology of organisms. One such compound is 17α-ethinyl estradiol (EE2), a synthetic estrogen used in the contraceptive pill. Despite considerable research interest in the effects of EE2 on reproduction and gene expression, surprisingly, only a few studies have capitalised on technologies, such as next-generation sequencing (NGS), to uncover the molecular pathways related to EE2 exposure.

Herbicides and trace metals in urban waters in Melbourne, Australia (2011-12): concentrations and potential impact.

Urban stormwater samples were collected from five aquatic systems in Melbourne, Australia, on six occasions between October 2011 and March 2012 and tested for 30 herbicides and 14 trace metals. Nineteen different herbicides were observed in one or more water samples from the five sites; chemicals observed at more than 40% of sites were simazine (100%), MCPA (83%), diuron (63%) and atrazine (53%). Using the toxicity unit (TU) concept to assess potential risk to aquatic ecosystems, none of the detected herbicides were considered to pose an individual, group or collective short-term risk to fish or zooplankton in the waters studied.

Pesticide and trace metals in surface waters and sediments of rivers entering the Corner Inlet Marine National Park, Victoria, Australia.

Water and sediment samples were collected from up to 17 sites in waterways entering the Corner Inlet Marine National Park monthly between November 2009 and April 2010, with the Chemcatcher passive sampler system deployed at these sites in November 2009 and March 2010. Trace metal concentrations were low, with none occurring at concentrations with the potential for adverse ecological effects. The agrochemical residues data showed the presence of a small number of pesticides at very low concentration (ng/L) in the surface waters of streams entering the Corner Inlet, and as widespread, but still limited contamination of sediments.

POPs monitoring in Australia and New Zealand using plastic resin pellets, and International Pellet Watch as a tool for education and raising public awareness on plastic debris and POPs.

Persistent organic pollutants (i.e. PCBs, DDTs, and HCHs) were analyzed along Australia and New Zealand North Island coastlines.

Exposure to an agricultural contaminant, 17β-trenbolone, impairs female mate choice in a freshwater fish.

Despite the pivotal role sexual selection plays in population dynamics and broader evolutionary processes, the impact of chemical pollution on female mate choice is poorly understood. One group of chemical contaminants with the potential to disrupt the mechanisms of female mate choice is endocrine disrupting chemicals (EDCs); a broad class of environmental pollutants that can interfere with the endocrinology of organisms at extremely low concentrations. Recent research has revealed that estrogenic EDCs can affect female mate choice in fish, but the impact of androgenic EDC exposure is yet to be studied.

Combining Passive Sampling with Recombinant Receptor-Reporter Gene Bioassays to Assess the Receptor Activity of Victorian Rivers.

This pilot study was initiated to provide new information on the 'hormonal' activity of Victorian rivers. Chemcatcherâ„¢ passive sampler systems containing Emporeâ„¢ C18FF disks were deployed at eight riverine sites near Melbourne. Little estrogenic activity [<0.

Sex in troubled waters: Widespread agricultural contaminant disrupts reproductive behaviour in fish.

Chemical pollution is a pervasive and insidious agent of environmental change. One class of chemical pollutant threatening ecosystems globally is the endocrine disrupting chemicals (EDCs). The capacity of EDCs to disrupt development and reproduction is well established, but their effects on behaviour have received far less attention.