Publications by authors named "Alliefair Scalise"
Lipedema and lymphedema are physically similar yet distinct diseases that are commonly misdiagnosed. We previously reported that lipedema and lymphedema are associated with increased risk for venous thromboembolism (VTE). The underlying etiology of the prothrombotic profile observed in lipedema and lymphedema is unclear, but may be related to alterations in platelets.
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- The study investigates the thrombosis risk and platelet function in patients with postacute sequelae of COVID-19 (PASC), also known as Long COVID, approximately 15 months after SARS-CoV-2 infection.
- Findings showed a mild increase in platelet aggregation through the thromboxane receptor but a decrease in activation through the glycoprotein VI receptor, alongside reduced thrombosis and Factor Xa activity in PASC patients compared to healthy controls.
- The results suggest a dysregulated platelet response in PASC patients, potentially due to a circulating molecule promoting thrombosis, as well as a protective mechanism that counteracts the increased thrombosis associated with SARS-CoV-2 infection.
Article Synopsis
- Post-acute sequelae of COVID-19 (PASC), also known as Long-COVID, can lead to changes in platelet function and thrombosis risk, which are not fully understood.
- A study compared PASC patients to healthy controls 15 months post-infection, assessing platelet activation and thrombosis potential through various tests.
- Findings indicated altered platelet responses in PASC patients, including increased activation through the thromboxane receptor and a protective mechanism against thrombosis, suggesting a complex interplay of pro- and anti-thrombotic factors following COVID-19.