and cortical superficial siderosis in CAA: Meta-analysis and potential mechanisms.

Objective: To assess potential mechanisms of cortical superficial siderosis (cSS), a central MRI biomarker in cerebral amyloid angiopathy (CAA), we performed a collaborative meta-analysis of associations with cSS presence and severity.

Methods: We pooled data from published studies reporting genotype and MRI assessment of cSS in 3 distinct settings: (1) stroke clinic patients with symptomatic CAA (i.e.