Publications by authors named "Allen Razavi"
Off-Pump Coronary Artery Bypass Grafting is Overutilized.
Semin Thorac Cardiovasc Surg
December 2024
Off-pump coronary artery bypass grafting (CABG), developed to avoid the potential complications of cardiopulmonary bypass, remains a subject of debate. Studies have demonstrated that off-pump CABG is associated with higher rates of incomplete revascularization, inferior graft patency, and increased reintervention rates compared to on-pump CABG, leading to worse outcomes. The theoretical neuroprotective and renal-protective benefits associated with off-pump CABG have not been definitively proven, with stroke and renal failure rates similar to those of on-pump CABG in both short- and long-term follow-up.
View Article and Find Full Text PDFBackground: The Commission on Cancer (CoC) established quality measures to be reported in National Cancer Database (NCDB) Quality Reporting Tools. Compliance is provided to accredited cancer programs as Cancer Program Practice Profile Reports (CP3R). At the time of this study, the quality metric for gastric cancer (GC) was removal and pathologic examination of 15 regional lymph nodes for resected GC (G15RLN).
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- - New research reveals that acute myocardial infarction (AMI) heightens inflammation and MMP-9 activity in the kidney, underscoring a need for better understanding of this response.
- - A study involving swine showed that using Impella support before heart reperfusion decreased MMP-9 levels and reduced kidney damage compared to ischemia-reperfusion or VA-ECMO methods.
- - Impella support not only lessened heart injury but also mitigated harmful kidney signaling pathways, suggesting it may offer protective benefits during cardiac events like AMI.
Article Synopsis
- * IVC occlusion decreased left ventricular pressures, volumes, cardiac output, and mean arterial pressure, while SVC occlusion mainly reduced left ventricular diastolic pressure and volumes without impacting cardiac output.
- * The preCARDIA system, a new technology for SVC occlusion, showed promise in achieving stable cardiac function while reducing filling pressures, and will be further evaluated in the upcoming VENUS-HF trial.
Article Synopsis
- * Researchers have investigated whether using mechanical support pumps to lower the heart's oxygen demand can decrease heart damage in AMI since the 1970s.
- * Recent studies, including the Door to Unload ST-segment Elevation Myocardial Infarction (DTU-STEMI) pilot trial, have focused on modern circulatory support pumps to explore this approach further.
Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable growth kinetics, making them useful for trialing novel therapeutics. Here, we describe surgical techniques for orthotopic and heterotopic pancreatic ductal adenocarcinoma (PDAC) tumor implantation and characterize phenotypes based on implantation site.Mice (=8 per group) were implanted with 10 cells in the pancreas or flank.
View Article and Find Full Text PDFWe report the development and optimisation of an assay for quantitating iron from iron oxide nanoparticles in biological matrices by using ferene-s, a chromogenic compound. The method is accurate, reliable and can be performed with basic equipment common to many laboratories making it convenient and inexpensive. The assay we have developed is suited for quantitation of iron in cell culture studies with iron oxide nanoparticles, which tend to manifest low levels of iron.
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