Publications by authors named "Allen Louie"
Background: Exposure to air pollution is associated with worldwide morbidity and mortality. Diesel exhaust (DE) emissions are important contributors which induce vascular inflammation and metabolic disturbances by unknown mechanisms. We aimed to determine molecular pathways activated by DE in the liver that could be responsible for its cardiometabolic toxicity.
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- Inflammatory bowel disease (IBD) is influenced by genetic, microbial, and environmental factors, with rising global cases linked to air pollution.
- Previous studies show that particulate matter (PM), especially ultrafine particles (UFP), promotes intestinal inflammation; however, UFP's effect on IBD has not been extensively studied.
- In experiments with mice, exposure to different ambient PM types showed no significant impact on weight, disease activity, or tissue inflammation during chemically-induced colitis, indicating UFP inhalation does not worsen acute IBD symptoms.
Exposure to ultrafine particles (UFPs) has been associated with multiple adverse health effects. Inhaled UFPs could reach the gastrointestinal tract and influence the composition of the gut microbiome. We have previously shown that oral ingestion of UFPs alters the gut microbiome and promotes intestinal inflammation in hyperlipidemic Ldlr mice.
View Article and Find Full Text PDFGlyphosate was classified as a probable human carcinogen (Group 2A) by the International Agency for Research on Cancer (IARC) partially due to strong mechanistic evidence in 2015. Since then, numerous studies of glyphosate and its formulations (GBF) have emerged. These studies can be evaluated for cancer hazard identification with the newly described ten key characteristics (KC) of carcinogens approach.
View Article and Find Full Text PDFBackground: The ability to induce chronic inflammation and immunosuppression are two key characteristics of carcinogens and important forms of immunotoxicity. The National Toxicology Program (NTP) evaluated the immunotoxicity of two per- and polyfluoroalkyl substances (PFASs), PFOA (perfluorooctanoic acid) and PFOS (perfluorooctane sulfonate), in 2016. However, the potential pro-inflammatory and immunosuppressive effects of other PFASs remain largely uncharacterized.
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