Publications by authors named "Allen E MacDonald"
J Pharmacol Exp Ther
May 2010
Article Synopsis
- Halothane is an inhaled anesthetic that can cause severe liver injury, known as "halothane hepatitis," affecting about 1 in 20,000 patients, with specific risk factors identified such as female sex and genetics.
- Researchers developed a mouse model to mimic human halothane hepatitis, finding that female mice were more prone to serious liver damage compared to males, especially under fasting conditions.
- The study revealed that the severity of liver injury in female mice was linked to a stronger immune response, highlighting the importance of neutrophils in the liver damage caused by halothane exposure.
