Publications by authors named "Allen Caobi"
Article Synopsis
- Extracellular vesicles (EVs), particularly exosomes (xEVs), have been linked to the progression of Diffuse Large B-cell Lymphoma (DLBCL) and contain important biomolecules such as proteins and nucleic acids.
- In the context of HIV, the expression of these xEVs has been associated with disease progression, highlighting their potential clinical relevance.
- Research indicates that the biomolecules in xEVs can aid in detecting disease progression and may help in predicting treatment outcomes for DLBCL, particularly in HIV-infected patients.
SARS-CoV-2 exhibits a remarkable capability to subvert the host antiviral innate immune system. This adeptness is orchestrated by viral proteins, which initially attempt to obstruct the activation of the antiviral immune program and then act as a fail-safe mechanism to mitigate the downstream effects of the activated immune response. This dual strategy leads to delayed expression and enfeebled action of type-I and -III interferons at the infection site, enabling the virus to replicate extensively in the lungs and subsequently disseminate to other organs.
View Article and Find Full Text PDFLiquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages of cancer. The fluid from these biopsies contains extracellular vesicles (EVs), such as apoptotic bodies, microvesicles, exomeres, and exosomes. Exosomes contain proteins and nucleic acids (DNA/RNA) that can modify the microenvironment and promote cancer progression, playing significant roles in cancer pathology.
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- Opiate abuse is linked to a higher risk of HIV transmission and worsens HIV-related nerve damage by affecting inflammation and immune responses.
- This study focuses on the development of a unique exosomal miRNA biomarker profile for HIV-infected cells, specifically looking at how morphine influences these miRNAs.
- Findings indicate that HIV and morphine together alter miRNA levels, which can impact neuronal function, suggesting potential new targets for treatment or understanding the disease mechanisms.
Exosomal extracellular vesicles (xEVs) in plasma and cerebrospinal fluid (CSF) of aviremic people living with HIV/AIDS (PLWHA) contain the HIV Negative factor (Nef) protein. However, the role of xEVs and Nef-containing-xEVs(xEV-Nef) in HIV-associated neuropathology is unknown. Here we performed a cross-sectional analysis of the content of xEVs derived from matched serum and CSF samples of PLWHAs diagnosed with either asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND), or HIV-associated dementia (HAD).
View Article and Find Full Text PDFIn recent years, new nicotine delivery methods have emerged, and many users are choosing electronic cigarettes (e-cigarettes) over traditional tobacco cigarettes. E-cigarette use is very popular among adolescents, with more than 3.5 million currently using these products in the US.
View Article and Find Full Text PDFMost cells can release extracellular vesicles (EVs), membrane vesicles containing various proteins, nucleic acids, enzymes, and signaling molecules. The exchange of EVs between cells facilitates intercellular communication, amplification of cellular responses, immune response modulation, and perhaps alterations in viral pathogenicity. EVs serve a dual role in inhibiting or enhancing viral infection and pathogenesis.
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- * The CRISPR-Cas9 gene-editing tool shows potential in treating these conditions by correcting harmful gene mutations and deleting problematic genes, which could alleviate symptoms of various diseases.
- * This review discusses the promising applications of genome editing, particularly in enhancing cancer treatment effectiveness and addressing inflammatory diseases like arthritis among the aging demographic.
Support of somatic growth is a fundamental requirement of tissue-engineered valves. However, efforts thus far have been unable to maintain this support long term. A key event that will determine the valve's long-term success is the extent to which healthy host tissue remodeling can occur on the valve soon after implantation.
View Article and Find Full Text PDF(commonly known as blue pea) flower petal extract (CTE) is used as a natural colorant in a variety of foods and beverages. The objective of study was to determine the inhibitory effect of CTE on adipogenesis in 3T3-L1 preadipocytes. The phytochemical profiles of CTE were analyzed by liquid chromatography and tandem mass spectrometry (LC-MS/MS).
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- Multiple sclerosis (MS) is a disorder where the immune system attacks the protective covering of nerves, with causes that are not fully understood, but likely include genetic factors and environmental influences like vitamin D deficiency and certain viral infections.
- The disease progression is linked to activated T cells that promote inflammation, leading to nerve damage through demyelination and axonal injury.
- Understanding the risk factors and mechanisms behind T cell activation is crucial for developing effective treatments for MS, as highlighted in the detailed review of existing literature on both harmful and non-harmful influences on the disease.