Time to clinically significant visual acuity gains after ranibizumab treatment for retinal vein occlusion: BRAVO and CRUISE trials.

Purpose: To assess time to first achievement of clinically significant visual acuity (VA) gains from baseline in patients with retinal vein occlusion (RVO) receiving ranibizumab versus sham treatment.

Design: Post hoc analyses of 2 phase 3 clinical trials assessing efficacy and safety of ranibizumab in patients with branch RVO (Ranibizumab for the Treatment of Macular Edema following Branch Retinal Vein Occlusion: Evaluation of Efficacy and Safety [BRAVO] study; NCT00061594) and central RVO (Ranibizumab for the Treatment of Macular Edema after Central Retinal Vein Occlusion Study: Evaluation of Efficacy and Safety [CRUISE]; NCT00056836) over 12 months.

Participants: Seven hundred eighty-nine patients (BRAVO, n = 397; CRUISE, n = 392).

Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study.

Objectives: To determine the long-term effects of ranibizumab (RBZ) in patients with diabetic macular edema (DME).

Design: Prospective, randomized, interventional, multicenter clinical trial.

Participants: One hundred twenty-six patients with DME.

Severe eye injuries in the war in Iraq, 2003-2005.

Purpose: To document the incidence and treatment of patients with severe ocular and ocular adnexal injuries during Operation Iraqi Freedom.

Design: Retrospective hospital-based observational analysis of injuries.

Participants: All coalition forces, enemy prisoners of war, and civilians with severe ocular and ocular adnexal injuries.

Feasibility of telerobotic microsurgical repair of corneal lacerations in an animal eye model.

We evaluated the feasibility of telerobotic microsurgical repair of corneal lacerations. The telerobotic microsurgical device consisted of a Robotic Slave Micromanipulator Unit (RSMU) coupled to a Telepresence Surgical System (TeSS). Five mm central full-thickness corneal wounds were fashioned in five enucleated rabbit eyes and repaired remotely using the telerobotic system.

Intraocular foreign body injuries during Operation Iraqi Freedom.

Objective: To evaluate the number of intraocular foreign body (IOFB) injuries that occurred in Operation Iraqi Freedom, and to determine the cause of injury, the type of foreign body, and the associated injuries to other body systems.

Design: Retrospective, noncomparative, interventional case series.

Participants: Fifty-five United States military personnel with an IOFB injury during Operation Iraqi Freedom.

Large-spot size transpupillary thermotherapy for the treatment of occult choroidal neovascularization associated with age-related macular degeneration.

Objective: To describe the outcome of patients with occult choroidal neovascularization in age-related macular degeneration treated with transpupillary thermotherapy.

Design: Prospective, nonrandomized, nonmasked case series.

Methods: All patients with age-related macular degeneration with a predominantly occult choroidal neovascular membrane and an initial visual acuity of 20/400 or better were offered treatment using transpupillary thermotherapy.

Teleophthalmology in the evaluation of ocular trauma.

Objective: The objective of this investigation is to evaluate the efficacy of teleophthalmology in the assessment of anterior segment and ocular adnexal trauma using digital imaging devices.

Methods: Eight ocular injuries were created in an animal model. Two separate photographers of different skill levels photographed each injury using four different cameras.

Homocysteine: a risk factor for retinal venous occlusive disease.

Purpose: Recent studies have shown a relationship between elevated levels of homocysteine and vascular disease including cerebrovascular accidents and myocardial infarctions. We evaluated patients with a recent retinal vein occlusion to determine if there was an associated elevation of homocysteine.

Design: Age and gender matched case-controlled study.