Publications by authors named "Allana Faustino Martins"
Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health.
Fernanda Aparecida Dos Santos France Debora Kazumi Maeda Ana Beatriz Rodrigues Mai Ono Franciele Lopes Nogueira Marchetti Marcos Martins Marchetti Allana Cristina Faustino Martins
Epigenetics
December 2024
Article Synopsis
- A differential diet with royal jelly during honeybee larval development affects their phenotype, likely through epigenetic changes in gene expression.
- Research shows that royal jelly contains compounds, like 10-hydroxy-2-decenoic acid (10-HDA), that can inhibit enzymes known as histone deacetylases (HDACs), which are important for regulating gene activity.
- Experimental and computational analyses suggest that fatty acids from royal jelly, especially 10-HDA and 10-HDAA, may serve as weak HDAC inhibitors, promoting increased gene expression in human cancer cells.
Article Synopsis
- * The study revealed that cyclophosphamide alone increases genomic damage and decreases phagocytosis in Swiss male mice, but combining it with the resorcinolic lipid reduces genomic damage by up to 33.8%.
- * Molecular docking shows the resorcinolic lipid binds more strongly to DNA than cyclophosphamide's active metabolite, indicating its potential as both a therapeutic candidate and a chemotherapeutic adjuvant.
Some important atypical antipsychotic drugs target the serotonergic receptor 2A (5-HTR). Currently, new therapeutic strategies are needed to offer faster onset of action with fewer side effects and, therefore, greater efficacy in a substantial proportion of patients with neuropsychological disorders such as Autism and Parkinson. The main objective of this work was to use SBDD methods to identify new hit compounds potentially useful as precursors of novel and selective 5-HTR antagonists.
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