Publications by authors named "Allan Pavy"
Article Synopsis
- Cold piezoelectric plasma (CPP) is a new cancer treatment method that can lead to cancer cell death and the development of portable treatment devices, specifically targeting cholangiocarcinoma (CCA).
- In vitro experiments use two types of CPP devices, corona discharge (Pz-CD) and dielectric barrier discharge (Pz-DBD), with Pz-CD delivering more power but both generating significant reactive species.
- CPP shows immediate effects like remodeling of the actin cytoskeleton and long-term effects through activation of the DNA damage response pathway, suggesting its potential as an effective antitumor therapy.
The ectopic xenograft mouse model of cancer is a commonly employed tool for in vivo investigations, particularly for studying cell tumorigenicity and testing the efficacy and tolerability of systemic or local anti-cancer therapies. The model displays advantageous features with an easy-access to visualize and monitor tumor growth in real-time with a caliper. Although the tumor development occurs in an ectopic location, the histology of the tumor resembles that of human cancer upon pathological examination.
View Article and Find Full Text PDFThe Epidermal Growth Factor Receptor (EGFR) has been targeted through the development of selective tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAb). These molecules have shown effectiveness in a subset of patients with specific genetic alterations (i.e.
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