Development and Validation of a Stability-Indicating High-Performance Liquid Chromatography Method Coupled With a Diode Array Detector for Quantifying Haloperidol in Oral Solution Using the Analytical Quality-by-Design Approach.

This study developed a stability-indicating HPLC-DAD method for quantifying haloperidol in oral solution using analytical quality-by-design principles. Haloperidol stability was tested under acidic, alkaline, oxidative, and photolytic stress conditions. The analytical quality-by-design approach began by defining the analytical target profile and identifying critical material attributes and critical method parameters via risk analysis.

Pharmacokinetics of oral ciprofloxacin in adult patients: A scoping review.

Aims: To map the literature on oral ciprofloxacin's pharmacokinetics and its implications for dose adjustments in specific populations.

Methods: A scoping review was performed according to the Cochrane Collaboration and JBI and reported following the PRISMA-ScR. Systematic searches on electronic databases were conducted to integrate the current evidence on ciprofloxacin's pharmacokinetics.

LC-QToF-MS method for quantification of ethambutol, isoniazid, pyrazinamide and rifampicin in human plasma and its application.

In this research, we developed and validated a liquid chromatography coupled to mass spectrometry (LC-QToF-MS) method for simultaneous quantification of the anti-tuberculosis drugs ethambutol, isoniazid, pyrazinamide and rifampicin in human plasma. Plasma samples spiked with cimetidine (internal standard) were extracted using protein precipitation with acetonitrile containing 1% formic acid. Separation was performed using a C column under flow gradient conditions with water and acetonitrile, both containing 5 mm ammonium formate and 0.