Publications by authors named "Allan Jackson"
Article Synopsis
- The updated UK guidelines provide management recommendations for genital herpes simplex virus (HSV) during pregnancy and the first month after birth, addressing both first episodes and recurrences of HSV.
- They also cover scenarios such as preterm pre-labour rupture of membranes and co-infection with HIV, with specific advice on caring for newborns and preventing postnatal transmission.
- Aimed at healthcare professionals in various settings, including sexual health and maternity units, these guidelines emphasize that their principles should be applied to all care environments, including community services.
There are no internationally agreed descriptors for categories of neonatal transports which facilitate comparisons between settings. To continually review and enhance neonatal transport care we need robust categories to develop benchmarks. This review aimed to report on the development and application of key measures across a national neonatal transport service.
View Article and Find Full Text PDFParental presence during neonatal transfers conducted by a national transport service.
Arch Dis Child Fetal Neonatal Ed
March 2023
Background: Between 20% and 50% neonates with bilious vomiting are diagnosed with surgical pathology. Distinguishing neonates requiring surgery remains challenging. Our aim was to conduct an audit of term neonates with bilious vomiting referred for assessment to identify characteristics of this cohort and management.
View Article and Find Full Text PDFEnd-of-life care for many infants involves the withdrawal of mechanical ventilation. Usually this takes place in the hospital environment, but sometimes parents request that their infant dies at home. Facilitating this has significant practical and resource implications and raises both logistical and ethical questions.
View Article and Find Full Text PDFArticle Synopsis
- - Neonatal infections significantly contribute to infant illness and death worldwide, and understanding how newborns respond to these infections is still limited.
- - The study utilized whole blood transcriptome profiling to identify gene expression changes and biological pathways relevant to neonatal infection by analyzing blood samples from neonates suspected of sepsis compared to healthy controls.
- - A key finding was the development of a 52-gene classifier that can accurately predict bacterial infections in neonates, which could enhance diagnostic and treatment approaches for neonatal sepsis.
Understanding how human neonates respond to infection remains incomplete. Here, a system-level investigation of neonatal systemic responses to infection shows a surprisingly strong but unbalanced homeostatic immune response; developing an elevated set-point of myeloid regulatory signalling and sugar-lipid metabolism with concomitant inhibition of lymphoid responses. Innate immune-negative feedback opposes innate immune activation while suppression of T-cell co-stimulation is coincident with selective upregulation of CD85 co-inhibitory pathways.
View Article and Find Full Text PDFShould we be doing more than just talking?
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