Publications by authors named "Allan Dong"
Unexplained euploid embryo transfer failure (UEETF) is a frustrating and unanswered conundrum accounting for 30 to 50% of failures in in vitro fertilization using preimplantation genetic testing for aneuploidy (PGT-A). Endometriosis is thought by many to account for most of such losses and menstrual suppression or surgery prior to the next transfer has been reported to be beneficial. In this study, we performed endometrial biopsy in a subset of women with UEETF, testing for the oncogene BCL6 and the histone deacetylase SIRT1.
View Article and Find Full Text PDFArticle Synopsis
- - The 2017 American Thyroid Association Guidelines on thyroid disease during pregnancy and postpartum are outdated, as over 500 new articles have been published since then, emphasizing the need for more timely, evidence-based guidance for clinicians.
- - A systematic review of literature from March 2017 to December 2018 identified 659 articles on thyroid and pregnancy, narrowing down to 44 relevant studies on hypothyroidism and thyroid autoimmunity for discussion.
- - The authors propose two specific updates to the 2017 guidelines, including recommendations against treating thyroid antibody-negative women with subclinical hypothyroidism in the second trimester or later, based on new research findings.
Objective: To determine whether overt/subclinical hypothyroidism and/or thyroid autoimmunity is associated with recurrent pregnancy loss (RPL) and whether treatment improves outcomes.
Design: Systematic review and meta-analysis.
Setting: University obstetrics and gynecology departments.
Universal screening for thyroid disease during pregnancy should be performed.
Best Pract Res Clin Endocrinol Metab
July 2020
Thyroid disease can significantly impact the pregnant woman and her child. Human and animal studies have firmly linked overt hypothyroidism and overt hyperthyroidism to miscarriage, preterm delivery and other adverse pregnancy outcomes. Overt hypothyroidism and overt hyperthyroidism affect 1% of all pregnancies.
View Article and Find Full Text PDFA 22-year-old G1P1 Caucasian female had hysteroscopic removal of a perforated intrauterine device during which the steroid reservoir of the intrauterine device was lost. Isolated steroid reservoirs are radiolucent on plain film radiography. We located the reservoir in the peritoneal cavity with magnetic resonance imaging and removed it via laparoscopy.
View Article and Find Full Text PDFBackground: The reported prevalence of thyroid disease in pregnancy varies widely through the published literature. These discrepancies are due to differences in criteria for euthyroidism, nationality, iodine status, and gestational age at screening. As a result, currently, an accepted rate of prevalence does not exist for the various thyroid diseases in pregnancy.
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