Publications by authors named "Allam S"

Introduction The patient-centered care model emphasizes patient autonomy in recovery, acknowledging each individual's unique journey. Despite challenges in the healthcare system, this model has gained traction nationwide. Advances in healthcare technology have highlighted obstacles to independent decision-making.

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Background A2/A2B to B kidney transplantation has the potential to increase transplant access for traditionally disadvantaged blood group B minority candidates. Despite prior reports of positive post-transplant safety and clinical success, A2/A2B to B kidney transplantation remains underutilized in the United States. This study aims to investigate the post-transplant outcomes of A2/A2B to B kidney transplants performed at our center.

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Background: There are limited data on the effects of therapeutic anticoagulation (AC) on stroke and bleeding risk in patients with sepsis-induced atrial fibrillation (AF).

Objective: This study aimed to determine the effect of therapeutic AC on the development of inpatient strokes and significant bleeding in hospitalized patients with septic shock and AF.

Methods: This single-center, retrospective study examined 604 patients with septic shock and AF.

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We describe a new species of mite in the genus Nenteria Oudemans, collected from the Red Palm Weevil, Rhynchophorus ferrugineus (Oliver) (Coleoptera: Curculionidae), at Bahariya Oasis, Egypt. Nenteria bahariyaensis n. sp.

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Detection of light chain (LC) monoclonal gammopathies (MG) traditionally relies on serum free LC (FLC) κ, λ, and their ratio (κ/λ) reference ranges based on a mostly White population. We investigated FLC values in a racially diverse population by screening 10,035 individuals for heavy chain MG, identifying 9,028 negative cases whose FLC were measured. Participants included 4,149 from the PROMISE Study (US, n=2,383; South Africa, n=1,766) and 4,879 from the Mass General Brigham Biobank, with 44% self-identifying as Black.

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Objective: Giant cell arteritis (GCA) is a chronic inflammatory condition associated with a significantly increased risk of various cardiovascular and thromboembolic events. Existing studies suggest an increased risk of cardiovascular disease in GCA, but results vary. This meta-analysis aims to quantify the association between GCA and the risk of various cardiovascular outcomes, providing a comprehensive evaluation of the cardiovascular burden in patients with GCA.

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Background: Neurofibromatosis type-2-related schwannomatosis (-SWN, formerly neurofibromatosis type 2) is a rare genetic disorder marked by the development of multiple nervous system tumors.

Case Presentation: We report a 21-month-old female patient who presented for left eye deviation. Upon examination, intermittent exotropia and a fundus mass were detected.

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The rate of patients readmitted to hospitals within 30 days of discharge is a critical indicator of healthcare quality. This study explored the factors contributing to 30-day hospital readmission rates nationally and at Arrowhead Regional Medical Center (ARMC) through a mixed-methods research design. Quantitative analysis utilized data from the Centers for Medicare & Medicaid Services (CMS) database, focusing on patient demographics, principal diagnoses, length of stay, and hospital characteristics.

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Article Synopsis
  • - Cardiovascular diseases are the top global health issue, making accurate diagnosis crucial; artificial intelligence (AI) and machine learning (ML) are being explored for improving cardiovascular imaging techniques like echocardiography and MRI.
  • - The review highlights AI's potential in diagnosing various heart issues, such as coronary artery disease and arrhythmias, which could enhance diagnostic accuracy and personalized treatment.
  • - Despite its promise, challenges such as data quality, interpretability of AI models, and ethical concerns need to be addressed, requiring collaboration among clinicians, data scientists, and policymakers for effective implementation in healthcare.
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  • - Neurological disorders like Alzheimer's disease and Parkinson's disease affect over 50 million people globally and currently lack effective disease-modifying treatments, leading to a significant crisis in dementia care.
  • - Key proteins involved in these diseases—amyloid-beta (Aβ), tau, and alpha-synuclein (α-Syn)—are targets for new immunotherapies designed to promote clearance and protect neurons from damage while alleviating symptoms.
  • - Recent advancements in disease-modifying therapies (DMTs) involving anti-Aβ and anti-αSyn monoclonal antibodies are being explored in clinical trials, focusing on improving cellular mechanisms that clear these harmful proteins from the brain.
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Linear induction machines (LIMs) find widespread adoption in various applications, owing to their inherent advantages such as low noise, compact turning radius, and excellent climbing capability. LIMs are extensively utilized in linear metro applications. However, in practical operations, the output thrust shrinks with the increase in speed, which is attributed to end effects.

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Nanobiocatalysts (NBCs), which merge enzymes with nanomaterials, provide a potent method for improving enzyme durability, efficiency, and recyclability. This review highlights the use of eco-friendly synthesis methods to create sustainable nanomaterials for enzyme transport. We investigate different methods of immobilization, such as adsorption, ionic and covalent bonding, entrapment, and cross-linking, examining their pros and cons.

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Background: Sepsis remains a leading cause of death worldwide. In this context, heparin-binding protein (HBP) has emerged as a possible biomarker, drawing significant attention for its diagnostic and prognostic usefulness in septic patients. Despite this advancement, the literature yields conflicting results.

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Article Synopsis
  • * Moringa oleifera was tested for its antibacterial properties against these isolates, revealing varying minimum inhibition concentrations (MIC) that demonstrated its effectiveness, particularly against E. coli and Klebsiella pneumoniae.
  • * Genetic analysis showed high levels of virulent gene profiles, with 83% of E. coli isolates producing Shiga toxins and resistance genes, suggesting both pathogenicity and multi-drug resistance in the bacteria studied.
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Background: Nurses constitute the largest body of healthcare professionals globally, positioning them at the forefront of enhancing patient safety. Despite their crucial role, there is a notable gap in the literature regarding the comprehension and competency of nursing students in patient safety within Egypt. This gap underscores the urgent need for research to explore how nursing students perceive patient safety and the extent to which these competencies are integrated into their clinical and educational experiences.

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This research work was planned to test biosafety of different nanomaterials on the different animals models. These nanoparticles were previously used as potential insecticides of mosquito larvae. The biosafety of these nanoproducts were evaluated on certain organs of non target animals that associated with mosquito breeding sites in Egypt.

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Background: Ehrlich ascites carcinoma (EAC) is a rapidly growing and undifferentiated tumor that can prompt oxidative stress and liver toxicity, whereas chitosan and have widely recognized biological qualities. Therefore, our study designed to assess the potential ameliorative ability of chitosan nanoparticles (CS NPs) and Grifola Frondosa nanoparticles (GF-loaded casein NPs) on EAC-induced hepatic injury in mice.

Methods: A total of 60 female albino mice were segregated into 6 groups (10 mice each), G1, control group; G2, CS NPs group; G3, GF-loaded casein NPs group; G4, EAC group; G5, EAC treated with CS NPs; G6, EAC treated with GF-loaded casein NPs.

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Background: In recent years, there has been a marked growth in the use of ionizing radiation in medical imaging for both diagnosis and therapy, which in turn has led to increased radiation exposure among healthcare workers.

Aim: The purpose of this study was to assess the level of safety compliance awareness among healthcare workers exposed to ionizing radiation.

Research Design: A descriptive cross-sectional design was used for this investigation.

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The hospitality industry is well-known for its challenging and high-pressure work settings. In this context, employees commonly face a multitude of stressors originating from their roles and job responsibilities, which can significantly impact their psychological wellbeing. Hence, based on the job demands-resources (JD-R) model and the spillover theory, this study aims to empirically explore the direct and indirect effect of work stress (assessed by role overload, ambiguity, and conflict) on psychological distress among frontline employees in 3- and 4-star Egyptian resorts while considering the mediating influence of work-family conflict (WFC).

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Article Synopsis
  • Intratumoral bacteria, specifically Colibactin-producing (CoPEC) strains, are linked to tumor heterogeneity and cancer recurrence by creating a low-immunity environment in right-sided colorectal tumors.
  • These bacteria foster lipid accumulation in cancer cells, which helps them survive and resist chemotherapy, correlating with worse survival rates in advanced-stage colorectal cancer patients.
  • Targeting the metabolic changes induced by CoPEC with specific inhibitors has shown potential in restoring chemotherapy sensitivity, suggesting a new approach to improve treatment outcomes for patients colonized by these bacteria.
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In this study, the impact of chitosan (CS) and maitake (GF) nanoparticles towards the renal toxicity induced by Ehrlich ascites carcinoma (EAC) in vivo model was conducted. Besides benchmark negative control group, EAC model was constructed by intraperitoneal injection (i.p.

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Background Organs from extreme ages have been sought after to help increase the donor pool and alleviate transplantation wait times. There has been a growing evolution of the use of pediatric donor kidneys, including the use of en bloc kidneys (EBK), to now separating them into single kidneys (SKT), allowing for transplantation of two recipients. This study reports our outcomes utilizing SKT.

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Introduction: The herbal preparation STW 5 ameliorates functional dyspepsia partly by relaxing smooth muscle of the proximal stomach, thus improving gastric accommodation. We explored the unknown pathways responsible for this effect by testing targets known to modulate gastric smooth muscle relaxation.

Methods: STW 5-induced relaxation of smooth muscle strips from guinea pig gastric corpus before and after pharmacological interventions were recorded with force transducers in an organ bath.

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Background: Bacterial infections are considered a leading cause of hospitalization and death globally. There is still a need for a rapid and feasible biomarker for bacterial infections. Heparin-binding protein (HBP) was shown to be related to bacterial infections.

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