Publications by authors named "Allali Fadoua"

Introduction The objectives of this study are to assess the knowledge, attitudes, and practices of patients with chronic inflammatory rheumatism (CIR) about diet. Aiming to identify their level of understanding of the role of nutrition in symptom management, explore their perceptions about different types of foods, and analyze their current dietary habits. The study also aims to assess the impact of this knowledge and dietary changes on their CIR management.

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Anti-nuclear mitotic apparatus (NuMA) 1 antibodies are uncommonly detected in routine antinuclear antibody (ANA) screening. We present the case of a 65-year-old female with rheumatoid arthritis undergoing golimumab biotherapy who developed lupus-like symptoms including photosensitivity, fatigue, weakness, myalgias, alopecia, oral ulcers, and worsening of arthritis. Elevated serum levels of NuMA-1 antibodies were detected using indirect immunofluorescence (IIF) on HEp-2 cells with a titer of 1:1000, but no other ANA patterns were associated.

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Background and objective Secukinumab (SECU) is a biologic disease-modifying antirheumatic drug (bDMARD) that has demonstrated effectiveness against axial spondyloarthritis (ax-SpA). However, in clinical practice, secukinumab is most commonly used as a second-line treatment after failure of or intolerance to tumor necrosis factor inhibitors (TNFi). In this study, we aimed to compare the two-year drug retention between secukinumab and TNFi in biologic-naïve patients with ax-SpA, to estimate the remission/low disease activity (LDA) rates in both groups and assess the safety profiles.

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Article Synopsis
  • TMJ involvement in psoriatic arthritis (PsA) is rare but can cause significant pain and difficulty with jaw movement, as illustrated by a 35-year-old male patient with guttate psoriasis.
  • The patient experienced TMJ pain, decreased mouth opening, and symptoms of inflammatory pain in the lumbar and buttock regions, leading to a diagnosis of PsA.
  • Effective treatment with tumor necrosis factor alpha inhibitors resulted in full remission, highlighting the importance of timely diagnosis and management to prevent long-term TMJ damage and improve quality of life.
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Introduction: Our study aimed to evaluate the integration level of non-pharmacological management (NPM) for rheumatoid arthritis (RA), analyze attitudes, practices, and perceived barriers towards NPM implementation, and identify factors contributing to the underutilization of non-pharmacological treatment in RA.

Material And Methods: A descriptive and analytical cross-sectional study was conducted among rheumatologists in Morocco. Rheumatologists received an online questionnaire gathering sociodemographic data, NPM integration level for RA, exploring their attitudes, practices and perceived barriers regarding the integration of NPM for RA, using a Likert scale ranging from 1 to 5.

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  • H syndrome is a rare genetic condition characterized by skin changes (like hyperpigmentation and excessive hair growth) and affects multiple body systems due to a specific gene mutation.
  • A case study of a 24-year-old Moroccan male with insulin-dependent diabetes shows various symptoms, including skin issues and musculoskeletal problems like foot abnormalities and joint contractures.
  • The report emphasizes the serious rheumatological impacts of H syndrome and discusses potential treatments to help improve these musculoskeletal issues.
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  • * Data was collected through interviews and patient files, focusing on costs like productivity losses, formal care expenses, and intangible impacts on activities and relationships.
  • * Findings indicate significant financial burdens on patients, with annual costs averaging $2337.73 due to lost wages and notable intangible effects, particularly related to personal relationships and lifestyle changes.
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Certolizumab-induced liver injury is exceptionally rare, with only a few cases reported in the literature. We present the case of a 34-year-old man with axial ankylosing spondylitis (AS) who developed a drug-induced liver injury following treatment with certolizumab. Despite the initial ineffectiveness of non-steroidal anti-inflammatory drugs and an inadequate response to infliximab, the patient achieved remission of AS symptoms with certolizumab.

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  • Rheumatologists have limited knowledge about patients' use of complementary and alternative medicine (CAM) for rheumatic diseases, making it important to understand its prevalence and benefits to enhance patient care.
  • A study conducted at a Moroccan University Hospital found that 46% of participants used at least one CAM method, with cupping therapy being the most popular (36%), primarily for pain relief (55%).
  • The study indicated that patients with higher education levels were significantly less likely to use CAM, highlighting the influence of education on treatment choices and the perceived effectiveness of different CAM approaches.
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Objective: To evaluate the vaccination coverage of patients with chronic inflammatory rheumatic disease (CIRD) against influenza, pneumococcus, and COVID-19 and to determine, per the patients' point of view, the possible factors related to vaccination hesitation and/or refusal.

Methods: A cross-sectional study carried out by the vaccination working group of the Moroccan Society of Rheumatology, including patients with CIRD in Morocco. Information about vaccination coverage and reasons for non-vaccination against influenza, pneumococcal infection, and COVID-19 was collected.

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Introduction Non-radiographic axial spondyloarthritis (nr-axSpA) is within the spectrum of axial spondyloarthritis (axSpA). The emergence of the nr-axSpA concept, defined by the absence of significant erosive damage to the sacroiliac joints, has prompted numerous initiatives aimed at enhancing the early detection and management of this condition. The aim of the study was to assess the knowledge, attitudes, and practices related to the diagnosis and management of nr-axSpA by rheumatologists in Morocco.

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Article Synopsis
  • The study investigated characteristics of late-onset spondyloarthritis (SpA) in patients over 45 years old, comparing them to those with early-onset SpA aged 45 or younger.
  • Data were collected from the Moroccan registry of biological therapies, involving 194 patients, with 31 classified as having late-onset SpA.
  • Key findings included that late-onset SpA patients had significantly more tender and swollen joints, higher rates of depression and fibromyalgia, but lower occurrences of coxitis compared to early-onset patients.
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Objectives: To describe and analyse the prevalence of extra-articular manifestations (EAMs) including acute anterior uveitis (AAU), psoriasis and inflammatory bowel disease (IBD) in patients with ankylosing spondylitis (AS) in the Moroccan registry of biological therapies in rheumatic diseases RBSMR (Registre des Biothérapies de la Société Marocaine de Rhumatologie).

Methods: A cross-sectional, multicentre and analytical study based on the RBSMR database, which included 170 AS. Incidence rates for the development of AAU, psoriasis and IBD were calculated, and risk factors were analysed.

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Objectives: The aim of this study was to determine the therapeutic maintenance level of methotrexate for rheumatoid arthritis patients enrolled in the Moroccan biotherapy registry and to identify predictive factors for discontinuing MTX treatment.

Methods: A cross-sectional study was conducted using the baseline data of the Moroccan biotherapy registry for RBSMR (a multicentric study that aims to evaluate tolerance of biological therapy on patients affected with rheumatic diseases). Demographics and disease features were compared using descriptive statistics.

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Background: The aim of this study was to evaluate the prevalence of active tuberculosis (TB) infection in Moroccan patients with rheumatic diseases under biologic therapy, and to describe the demographic characteristics of these patients as well as to explore potential risk factors.

Methods: This 14-year nationally representative multicenter study enrolled Moroccan patients with rheumatic diseases who had been treated with biologic therapy. Patient medical records were reviewed retrospectively for demographic characteristics, underlying rheumatic diseases, associated comorbidities, and TB-related data.

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Background: Kinesiotaping (KT) is widely used in several musculoskeletal disorders particularly in shoulder pain. However, literature shows controversial results regarding the effect of KT on shoulder pathology. The aim of this study was to assess the clinical effects of KT in the short term on rotator cuff tendinopathy (RCT).

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Objectives: To evaluate oral hygiene status in Rheumatoid arthritis (RA) patients, to analyse possible related factors, and to investigate the role of the rheumatologist in information about importance of adequate oral hygiene status in RA patients.

Methods: A cross-sectional study that included 100 consecutive RA patients (89% female, mean age 46.7 ± 11.

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  • Before starting biotherapy for rheumatic diseases, patients should be screened for latent tuberculosis infection (LTBI), and a study was conducted to assess the prevalence of LTBI in Moroccan patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA).
  • The study included 259 patients (94 with RA and 165 with SpA) and found an overall LTBI prevalence of 21.6%, with higher rates in SpA (24.8%) compared to RA (15.9%).
  • Demographic and clinical characteristics showed no significant differences between LTBI-positive and negative patients, indicating that being in a TB-endemic country like Morocco presents a notable risk for both RA and SpA patients.
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Introduction: the aim of our study is to determine, from data of the Moroccan register of biotherapies, the factors influencing the choice of the first prescribed biological treatment.

Methods: cross-sectional multicenter study including rheumatoid arthritis patients who were initiated the first biological treatment either: Rituximab, an anti-TNF, or Tocilizumab. The determinants related to the patient and disease have been gathered.

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The aim of the study was to estimate the annual direct costs of biological therapies in rheumatoid arthritis (RA), and to establish possible factors associated with those costs. The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry). We included patients with available 1-year data.

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Pre-extensively drug resistant tuberculosis (pre-XDR-TB) has been an area of growing concern, and posing a threat to global efforts of TB control. We report a case of PreXDR-TB spondylodiscitis with resistance to a Fluoroquinolone, in an immunocompetent patient under antibacillary treatment for pleural tuberculosis, managed with drug sensitivity-based second-line antituberculous drug regimen. Our case shows the challenges of the diagnostic and management of Drug-resistant TB spondylodiscitis.

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  • A consensus was formed by 15 expert physicians to create guidelines for the use of platelet-rich plasma (PRP) injections as a treatment for knee osteoarthritis, inspired by the French National Authority for Health recommendations.
  • The study involved a thorough literature review, and from this, 25 recommendations for PRP use were developed, focusing on their efficacy and application based on expert agreement.
  • Key recommendations concluded that PRP injections are beneficial for early to moderate knee osteoarthritis, advocate for 1-3 injections per treatment, and suggest the use of leucocyte-poor PRP to maximize effectiveness.
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