Tolerance of Biopronil Spot on® after repeated single- or multiple-dose topical treatments in dogs.

A variety of toxic effects of fipronil (FIP), the active substance of Biopronil Spot on on animals and humans has been reported and raises the need to investigate the FIP toxic effects. The objectives of the study were the evaluation of the local and systemic tolerance of Biopronil Spot on and the assessment of its influence on haematological and biochemical blood parameters after single and multiple topical treatment in dogs. Thirty-two mixed breed dogs were included in the study assessing the local and general tolerance of Biopronil Spot on following single, triple and fivefold dose after spot-on multiple applications in dogs (on days 0, +28 and +56) at a dosage 134 mg for a dog weighing 10-20 kg and 268 mg for a dog weighing 21-40 kg.