Post-stress changes in the gut microbiome composition in rats with different levels of nervous system excitability.

The gut-brain axis is a critical communication system influencing the interactions between the gastrointestinal tract (GI) and the central nervous system (CNS). The gut microbiota plays a significant role in this axis, affecting the development and function of the nervous system. Stress-induced psychopathologies, such as depression and anxiety, have been linked to the gut microbiota, but underlying mechanisms and genetic susceptibility remain unclear.

gene polymorphisms: association with age-related macular degeneration in Russian population.

Aim: To study polymorphisms in promotor regions of (rs1800630), (rs1800629), and (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex genotypes with AMD.

Methods: One hundred and two patients (82 women, 20 men; mean age 64.2±1.

Polymorphism of Immune Response Genes as a Factor for Predisposition to Development of Diseases.

The association of particular allelic variants of genes coding proteins, such as transporter associated with processing (TAP) and heat shock protein (HSP), involved in endocellular processing of endogenous antigens, with synovium pathology accompanied with urogenital infection was observed. The particular alleles of TAP1 and TAP2 genes appeared to be the factor of predisposition or resistance for Chlamidia trachomatis but not for Mycoplasma hominis. At the same time, the relative risk for C.