Publications by authors named "Alla O Nikolskaya"
Producing a tissue-engineered pancreas based on a tissue-specific scaffold from a decellularized pancreas, imitating the natural pancreatic tissue microenvironment and the islets of Langerhans, is one of the approaches to treating patients with type 1 diabetes mellitus (T1DM). The aim of this work was to investigate the ability of a fine-dispersed tissue-specific scaffold (DP scaffold) from decellularized human pancreas fragments to support the islets' survival and insulin-producing function when injected in a streptozotocin-induced diabetic rat model. The developed decellularization protocol allows us to obtain a scaffold with a low DNA content (33 [26; 38] ng/mg of tissue, < 0.
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- The authors found that the transdermal therapeutic system (TTS) for the immunomodulator ADPS provides similar drug absorption as intramuscular injections, but with lower peak blood levels and extended duration in the body.
- The study aimed to explore whether this transdermal method could enhance liver regeneration after extensive liver resection (ELR).
- Results showed that 48 hours after ELR, the ADPS TTS significantly increased liver cell activity and improved recovery rates in rats compared to the control group by 72 hours post-surgery.